Imaging of primary Ewing sarcoma with /sup 13/N-L-glutamate

Journal Article · Mon Feb 01 00:00:00 EST 1982 · Radiology; (United States)

OSTI ID:5504998

Reiman, R E; Rosen, G; Gelbard, A A; Benua, R S; Laughlin, J S

Eleven patients with untreated primary Ewing sarcoma were studied with intravenously administered /sup 13/N-labeled L-glutamate. Seven were repeatedly scanned during chemotherapy using this agent and /sup 99m/Tc-methylene diphosphonate (/sup 99m/Tc-MDP). The untreated primary tumor was distinctly visualized with /sup 13/N-L-glutamate in all cases; the distribution of /sup 13/N label in the tumor sometimes differed from that of /sup 99m/Tc. A kinetic study showed rapid uptake of /sup 13/N by tumor tissue. Repeat scans following therapy indicated that /sup 13/N-L-glutamate and /sup 99m/Tc-MDP uptake showed changes consistent with histological findings following subsequent surgery. /sup 13/N uptake often decreased more markedly than /sup 99m/Tc uptake during chemotherapy, but metastatic lesions were not visualized with /sup 13/N-L-glutamate. Tumor imaging with this labeled amino acid may be of value in assessing the response of primary Ewing sarcoma to chemotherapy.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York
• OSTI ID: 5504998
• Journal Information: Radiology; (United States), Vol. 142:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
SARCOMAS
DIAGNOSIS
SKELETON
SCINTISCANNING
AMINO ACIDS
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
INTRAVENOUS INJECTION
LABELLED COMPOUNDS
NITROGEN 13
PATIENTS
PHOSPHONIC ACID ESTERS
SKELETAL DISEASES
TECHNETIUM 99
UPTAKE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
THERAPY
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics