Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium
Twenty-two patients with biopsy-proved para-aortic lymph node metastases from carcinoma of the cervix (15 patients) or endometrium (7 patients) received a median dose of 5,000 rad/25 fractions. Para-aortic nodal metastases were controlled in 77% of cases. Control was significantly lower following radical retroperitoneal lymph node dissection than less extensive sampling procedures. Obstruction of the small bowel developed in 3 patients with tumor recurrence in the para-aortic region. Eight of the 10 patients who were disease-free at 2 years received >5,000 rad. Three patients were still alive without disease at 129, 63, and 60 months, respectively. The 5-year disease-free survival rate was 40% for cervical cancer and 60% for endometrial cancer: in the former group, it was significantly different depending on whether the para-aortic nodes were irradiated (40%) or not (0%). The authors suggest that 5,000-5,500 rad in 5-5.5 weeks is well tolerated and can control aortic nodal metastases in cervical and possibly endometrial cancer.
- Research Organization:
- Medical Coll. of Wisconsin Affiliated Hospitals, Milwaukee
- OSTI ID:
- 5504913
- Journal Information:
- Radiology; (United States), Vol. 147:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANOREXIA
RADIOINDUCTION
DIARRHEA
FISTULAE
NAUSEA
PROCTITIS
RADIOTHERAPY
SIDE EFFECTS
CARCINOMAS
HARD X RADIATION
LYMPH NODES
METASTASES
PATIENTS
UTERUS
BODY
DIGESTIVE SYSTEM DISEASES
DISEASES
ELECTROMAGNETIC RADIATION
FEMALE GENITALS
IONIZING RADIATIONS
LYMPHATIC SYSTEM
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
RADIATIONS
RADIOLOGY
SYMPTOMS
THERAPY
X RADIATION
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man