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Title: Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium

Abstract

Twenty-two patients with biopsy-proved para-aortic lymph node metastases from carcinoma of the cervix (15 patients) or endometrium (7 patients) received a median dose of 5,000 rad/25 fractions. Para-aortic nodal metastases were controlled in 77% of cases. Control was significantly lower following radical retroperitoneal lymph node dissection than less extensive sampling procedures. Obstruction of the small bowel developed in 3 patients with tumor recurrence in the para-aortic region. Eight of the 10 patients who were disease-free at 2 years received >5,000 rad. Three patients were still alive without disease at 129, 63, and 60 months, respectively. The 5-year disease-free survival rate was 40% for cervical cancer and 60% for endometrial cancer: in the former group, it was significantly different depending on whether the para-aortic nodes were irradiated (40%) or not (0%). The authors suggest that 5,000-5,500 rad in 5-5.5 weeks is well tolerated and can control aortic nodal metastases in cervical and possibly endometrial cancer.

Authors:
; ; ; ; ;
Publication Date:
Research Org.:
Medical Coll. of Wisconsin Affiliated Hospitals, Milwaukee
OSTI Identifier:
5504913
Resource Type:
Journal Article
Journal Name:
Radiology; (United States)
Additional Journal Information:
Journal Volume: 147:1
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANOREXIA; RADIOINDUCTION; DIARRHEA; FISTULAE; NAUSEA; PROCTITIS; RADIOTHERAPY; SIDE EFFECTS; CARCINOMAS; HARD X RADIATION; LYMPH NODES; METASTASES; PATIENTS; UTERUS; BODY; DIGESTIVE SYSTEM DISEASES; DISEASES; ELECTROMAGNETIC RADIATION; FEMALE GENITALS; IONIZING RADIATIONS; LYMPHATIC SYSTEM; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; PATHOLOGICAL CHANGES; RADIATIONS; RADIOLOGY; SYMPTOMS; THERAPY; X RADIATION; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man

Citation Formats

Komaki, R, Mattingly, R F, Hoffman, R G, Barber, S W, Satre, R, and Greenberg, M. Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium. United States: N. p., 1983. Web.
Komaki, R, Mattingly, R F, Hoffman, R G, Barber, S W, Satre, R, & Greenberg, M. Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium. United States.
Komaki, R, Mattingly, R F, Hoffman, R G, Barber, S W, Satre, R, and Greenberg, M. 1983. "Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium". United States.
@article{osti_5504913,
title = {Irradiation of para-aortic lymph node metastases from carcinoma of the cervix or endometrium},
author = {Komaki, R and Mattingly, R F and Hoffman, R G and Barber, S W and Satre, R and Greenberg, M},
abstractNote = {Twenty-two patients with biopsy-proved para-aortic lymph node metastases from carcinoma of the cervix (15 patients) or endometrium (7 patients) received a median dose of 5,000 rad/25 fractions. Para-aortic nodal metastases were controlled in 77% of cases. Control was significantly lower following radical retroperitoneal lymph node dissection than less extensive sampling procedures. Obstruction of the small bowel developed in 3 patients with tumor recurrence in the para-aortic region. Eight of the 10 patients who were disease-free at 2 years received >5,000 rad. Three patients were still alive without disease at 129, 63, and 60 months, respectively. The 5-year disease-free survival rate was 40% for cervical cancer and 60% for endometrial cancer: in the former group, it was significantly different depending on whether the para-aortic nodes were irradiated (40%) or not (0%). The authors suggest that 5,000-5,500 rad in 5-5.5 weeks is well tolerated and can control aortic nodal metastases in cervical and possibly endometrial cancer.},
doi = {},
url = {https://www.osti.gov/biblio/5504913}, journal = {Radiology; (United States)},
number = ,
volume = 147:1,
place = {United States},
year = {Fri Apr 01 00:00:00 EST 1983},
month = {Fri Apr 01 00:00:00 EST 1983}
}