Serotonin uptake in blood platelets of psychiatric patients

Journal Article · Tue Dec 01 00:00:00 EST 1981 · Arch. Gen. Psychiatr.; (United States)

DOI:https://doi.org/10.1001/archpsyc.1981.01780370024002· OSTI ID:5504171

Meltzer, H Y; Arora, R C; Baber, R; Tricou, B J

Platelet serotonin (5-HT) uptake was determined in 72 newly admitted, unmedicated psychiatric patients. Decreased maximum velocity (Vmax) of 5-HT uptake was present in unipolar and bipolar depressed patients as well as schizoaffective depressed patients. The apparent Michaelis constant (km) of 5-HT uptake was normal in these groups, as was Vmax and Km in manic-depressive and chronic schizophrenic patients. Treatment of depressed patients with notriptyline hydrochloride or imipramine hydrochloride increased Km significantly. There was a trend for the increase in Km in the nortriptyline-treated patients to correlate with clinical improvement. Decreased 5-HT uptake in platelets provides additional evidence for the role of 5-HT in the pathophysiologic process of some forms of depression.

• Research Organization: Department of Psychiatry, Pritzker School of Medicine, University of Chicago
• OSTI ID: 5504171
• Journal Information: Arch. Gen. Psychiatr.; (United States), Vol. 38:12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
MENTAL DISORDERS
BLOOD PLATELETS
SEROTONIN
UPTAKE
IMIPRAMINE
KINETICS
PATIENTS
TRANQUILIZERS
AMINES
ANTIDEPRESSANTS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
MATERIALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PSYCHOTROPIC DRUGS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
SYMPATHOMIMETICS
TRYPTAMINES
550600* - Medicine
551000 - Physiological Systems