Effect of copper administration on the incorporation of (3H)-thymidine into the liver DNA of rats stimulated by dimethylnitrosamine and diethylnitrosamine

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.12.1261· OSTI ID:5499797

Sakai, K; Murata, N; Chiba, K; Yamane, Y

The incorporation of (3H)thymidine into liver DNA of rats increased 6--8 times 48 h after a single injection of dimethylnitrosamine (DMN, 30 mg/kg) and diethylnitrosamine (DEN, 100 mg/kg). To test the suppressive effect of copper, the incorporation of (3H)thymidine into liver DNA in the DMN groups or DEN groups pretreated with copper was measured 48 h after the administration of DMN or DEN. The incorporation of (3H)thymidine into liver DNA of rats stimulated by the injection of DMN was strikingly suppressed by the injection of cupric acetate (20 mg Cu/kg), but that of rats stimulated by the injection of DEN was not suppressed by the injection of copper. Some other metal salts, silver nitrate (20 mg Ag/kg), nickel acetate (20 mg Ni/kg) and basic lead acetate (20 mg Pb/kg) did not significantly suppress the incorporation of (3H)thymidine stimulated by DMN or DEN. The accumulation of copper was much higher in the liver of copper-administered rats than that of nickel or lead in the liver of nickel-administered rats or lead-administered rats. The accumulation of silver was comparatively high in the liver of silver-administered rats.

• Research Organization: Faculty of Pharmaceutical Sciences, Chiba University, Japan
• OSTI ID: 5499797
• Journal Information: Carcinogenesis (N.Y.); (United States), Vol. 2:12
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
COPPER COMPOUNDS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
DNA REPLICATION
INHIBITION
NICKEL COMPOUNDS
NITROSAMINES
SILVER NITRATES
ACETATES
DNA
LIVER
RATS
TRITIUM COMPOUNDS
AMINES
ANIMALS
BODY
CARBOXYLIC ACID SALTS
DIGESTIVE SYSTEM
GLANDS
LABELLED COMPOUNDS
MAMMALS
NITRATES
NITROGEN COMPOUNDS
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RODENTS
SILVER COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)