Influence of dietary iron level and form on biochemical, hematological, and immunological changes in copper deficient rats
Weanling male Lewis rats (N = 10/group) were fed ad-libitum for 42 days diets based on AIN standards containing 21% casein, 5% safflower oil, deficient (0.6 ..mu..g/g) or adequate (5.6 ..mu..g/g) levels of Cu, and adequate (50 ..mu..g/g) or high (300 ..mu..g/g) levels of Fe/sup +2/ or Fe/sup +3/. Cu-deficient rats, regardless of Fe level or form, exhibited depressed (p < 0.05) serum Cu, Fe and ceruloplasmin activity, and hemoglobin levels; and elevated (p < 0.05) unsaturated serum Fe binding capacity. Except for high Fe/sup +3/ fed rats, Cu-deficient rats showed decreased hematocrits. Decreased proliferation was exhibited by concanavalin-A (Con-A) stimulated spleen lymphoid cells (SLC) of Cu-deficient rats fed adequate dietary Fe, but not by SLC of Cu-deficient rats fed high dietary Fe. High Fe fed rats exhibited reduced proliferation and increased variability in proliferation by Con-A stimulated SLC, which apparently caused a lack of difference in proliferation by SLC of Cu-deficient and Cu-adequate rats fed high Fe. Thus, high dietary Fe did not correct biochemical and hematological parameters in Cu-deficient rats, but because of lowered proliferation and increased variability of SLC proliferation, high dietary Fe did alleviate suppressed Con-A stimulated SLC proliferation in Cu-deficiency.
- Research Organization:
- Dept. of Agriculture, Grand Forks, ND
- OSTI ID:
- 5498199
- Report Number(s):
- CONF-8604222-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
COPPER
NUTRITIONAL DEFICIENCY
IRON
BIOLOGICAL EFFECTS
SPLEEN CELLS
CELL PROLIFERATION
BLOOD COUNT
CONCANAVALIN
DIET
HEMOGLOBIN
RATS
AGGLUTININS
ANIMAL CELLS
ANIMALS
ANTIBODIES
CARBOXYLIC ACIDS
ELEMENTS
GLOBIN
HEMAGGLUTININS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
LECTINS
MAMMALS
METALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
SOMATIC CELLS
TRANSITION ELEMENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)