Drug-mineral interactions

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5496733

Kramer, L

The effect of drugs such as glucocorticoids and thyroid extract on calcium metabolism is unknown. However, several other medications affect the excretion and intestinal absorption of calcium. A controlled study was carried out to investigate these aspects. Urinary calcium was determined for 3 months during the long-term intake of the antituberculous drug isoniazid (INH) and of the antibiotic tetracycline. The effect of the diuretics furosemide and hydrochlorothiazide, of several aluminum-containing antacids, of thyroid extract and of corticosteroids was also studied. Metabolic balances of calcium, phosphorus, magnesium and zinc were determined, as well as the intestinal absorption of calcium using Ca 47. Plasma levels, urinary and fecal excretions of Ca 47 were determined. All drugs tested increased urinary calcium except for the diuretic hydrochlorothiazide. Regarding the effect of corticosteroids: the intestinal absorption of calcium was unchanged after the short-term use and was very high after long-term use. The studies have shown that several commonly used drugs induce an increase in urinary calcium excretion which may contribute to calcium loss, if this increase persists for prolonged periods of time. Urinary excretions of phosphorus, magnesium and zinc increased in some of the studies.

• Research Organization: Veterans Administration Hospital, Hines, IL
• OSTI ID: 5496733
• Report Number(s): CONF-8604222-; TRN: 86-026670
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCIUM
EXCRETION
INTESTINAL ABSORPTION
CORTICOSTEROIDS
BIOLOGICAL EFFECTS
DIURETICS
TETRACYCLINES
CALCIUM 47
FECES
MAGNESIUM
METABOLISM
PHOSPHORUS
URINE
ZINC
ABSORPTION
ADRENAL HORMONES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CALCIUM ISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KETONES
MATERIALS
METALS
NONMETALS
NUCLEI
ORGANIC COMPOUNDS
PREGNANES
RADIOISOTOPES
STEROID HORMONES
STEROIDS
UPTAKE
WASTES
550501* - Metabolism- Tracer Techniques