Developmental effects of endocrine-disrupting chemicals in wildlife and humans
- W. Alton Jones Foundation and World Wildlife Fund, Washington, DC (United States)
- Univ. of Missouri, Columbia, MO (United States)
- Tufts Univ., Boston, MA (United States)
Large numbers and large quantities of endoncrine-disrupting chemicals have been released into the environment since World War II. Many of these chemicals can disturb development of the endocrine system and of the organs that respond to endocrine signals in organisms indirectly exposed during prenatal and/or early postnatal life; effects of exposure during development are permanent and irreversible. The risk to the developing organism can also stem from direct exposure of the offspring after birth or hatching. In addition, trangenerational exposure can result from the exposure of the mother to a chemical at any time throughout her life before producing offspring due to persistent of endocrine-disrupting chemicals in body fat, which is mobilized during egg laying or pregnancy and lactation. Mechanisms underlying the disruption of the development of vital systems, such as the endocrine, reproductive, and immune systems, are discussed with reference to wildlife, laboratory animals, and humans.
- OSTI ID:
- 5480516
- Journal Information:
- Environmental Health Perspectives; (United States), Vol. 101:5; ISSN 0091-6765
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ENDOCRINE GLANDS
INHIBITION
ORGANIC COMPOUNDS
BIOLOGICAL EFFECTS
ENVIRONMENTAL EXPOSURE
BIOLOGICAL PATHWAYS
ENDOCRINE DISEASES
HORMONE ANTAGONISTS
HUMAN POPULATIONS
ONTOGENESIS
PRENATAL EXPOSURE
REPRODUCTIVE DISORDERS
WILD ANIMALS
ANIMALS
BODY
DISEASES
DRUGS
GLANDS
ORGANS
POPULATIONS
560300* - Chemicals Metabolism & Toxicology
550500 - Metabolism
550900 - Pathology
551000 - Physiological Systems