Intraperitoneal radiolabeled OC 125 in patients with advanced ovarian cancer

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(89)90169-8· OSTI ID:5479479

Finkler, N J; Muto, M G; Kassis, A I; Weadock, K; Tumeh, S S; Zurawski, Jr, V R; Knapp, R C ^[1]

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1. Brigham and Women's Hospital, Boston, MA (USA)

Twenty patients with recurrent or persistent epithelial ovarian cancer failing conventional therapies were treated with a single intraperitoneal injection of iodine-131-labeled OC 125 monoclonal antibody. Rare acute side effects were nausea and mild diarrhea. At doses up to 120 mCi of iodine-131, median white blood cell and platelet count nadirs were 3.6k/microliters and 187k/microliters, respectively. Two patients acquired thyroid toxicities despite thyroid blockage with cold iodine. One patient had transient TSH elevation while remaining clinically euthyroid, and 1 patient developed activation of a thyroid nodule and clinical hyperthyroidism. Dose-limiting toxicity has not yet been observed. Twelve of 20 patients are alive 3 to 17 months following therapy. Tumor progression was noted in the majority of patients, although 3 patients had documented decreases in tumor burden of short duration. We conclude that, at the doses examined, iodine-131 OC 125 can be safely administered intraperitoneally.

• OSTI ID: 5479479
• Journal Information: Gynecologic Oncology; (USA), Vol. 34:3; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
IMMUNOTHERAPY
RADIOIMMUNOTHERAPY
RADIOTHERAPY
OVARIES
BLOOD COUNT
EPITHELIUM
ERYTHROCYTES
FEMALES
INTRAPERITONEAL INJECTION
IODINE 131
MONOCLONAL ANTIBODIES
PATIENTS
ANIMAL TISSUES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DISEASES
FEMALE GENITALS
GONADS
IMMUNOLOGY
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MATERIALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOIMMUNOLOGY
RADIOISOTOPES
RADIOLOGY
THERAPY
TISSUES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)