Chromosome breakage and sister chromatid exchange analysis in computer operators

Journal Article · Thu Jan 01 00:00:00 EST 1987 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528709375383· OSTI ID:5478172

Butler, M G; Yost, J; Jenkins, B B

Chromosome breakage analysis with Mitomycin C (MMC) and sister chromatid exchanges (SCE) were obtained on 10 computer operators with computer exposure for a minimum of 3 hours per day for 4 years and 10 control subjects matched for age and personal lifestyle. No difference was found between the two groups in the total number of chromatid and chromosome aberrations in cells grown at 48 and/or 96 hours in Mitomycin C (20 or 50 ng/ml-final concentration). The average number of SCE per cell in approximately 30 cells from each person was 6.4 +/- 1.1 (mean +/- standard deviation) for the computer operators and 9.2 +/- 1.6 for the controls. This difference was significant (p < .001). The replicative index was significantly higher (p < .01) in computer operators than in control subjects. The number of SCE appeared not to be influenced by the years of computer exposure. Additional studies with larger sample sizes will be needed to identify if significant differences exist in cell kinetics and sister chromatid exchanges in individuals employed as computer operators.

• Research Organization: Vanderbilt Univ. School of Medicine, Nashville, TN
• OSTI ID: 5478172
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Vol. A22:8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ELECTROMAGNETIC RADIATION
BIOLOGICAL EFFECTS
MAN
INJURIES
CHROMOSOME BREAKAGE
COMPUTERS
SISTER CHROMATID EXCHANGES
ANIMALS
CHROMOSOMAL ABERRATIONS
MAMMALS
MUTATIONS
PRIMATES
RADIATIONS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550400 - Genetics