Plasma clot-promoting effect of collagen in relation to collagen-platelet interaction

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Am. J. Vet. Res.; (United States)

OSTI ID:5476546

Gentry, P A ^[1]; Schneider, M D; Miller, J K

---

1. Comparative Animal Research Lab., Oak Ridge, TN

The hemostatic function of several acid-soluble collagen preparations and a fibrillar-form collagen preparation have been compared. Pepsin-treated acid-soluble collagen isolated from burro and horse aortic tissue and acid-soluble colagen isolated from human umbilical cord readily promoted platelet aggregation, but failed to activate the coagulation mechanism even after prolonged incubation with plasma at 37 C. By contrast, fibrillar-form collagen isolated from burro aorta was both an efficient stimulant for the induction of platelet aggregation and a potent clot-promoting agent. Similar results were found for all the collagen preparations irrespective of whether the studies were conducted with sheep or with burro plasma. Heat denaturation studies showed that the hemostatic functon of the fibrillar-form colagen was dependent on an intact tirple-helical structure.

• DOE Contract Number: AC05-760ROO242
• OSTI ID: 5476546
• Journal Information: Am. J. Vet. Res.; (United States), Vol. 42:5
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BLOOD PLATELETS
BLOOD COAGULATION
COLLAGEN
BIOLOGICAL EFFECTS
BURROS
CHEMICAL COMPOSITION
PHOSPHOLIPIDS
SHEEP
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
DOMESTIC ANIMALS
ESTERS
LIPIDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PROTEINS
RUMINANTS
SCLEROPROTEINS
VERTEBRATES
551000* - Physiological Systems
550200 - Biochemistry