Effects of postoperative adjuvant chemotherapy and radiotherapy on ovarian function in women undergoing treatment for soft tissue sarcoma
Ovarian function was evaluated in 11 women 16 to 43 years of age at treatment who received doxorubicin, cyclophosphamide, and high doses of methotrexate with or without radiotherapy in adjuvant therapy of soft tissue sarcoma. Five women (16-33 yr old) who received chemotherapy alone or combined with radiotherapy only at sites distant from the ovaries (chest wall, thigh, and leg) had minimal menstrual irregularities or temporary cessation of menses during therapy; cyclic menses returned promptly after therapy. Gonadotropin levels (expressed as means +/- SD (follicle-stimulating hormone (FSH), 10 +/- 5 mlU/ml; luteinizing hormone (LH), 10 +/- 4 mlU/ml) and 17 beta-estradiol (E2) levels (means +/- SD, 208 +/- 147 pg/ml) were normal. By contrast, 4 older women (ages 36-43 yr) who received similar treatment developed persistent amenorrhea with postmenopausal levels of gonadotropin (FSH, 108 +/- 29 mlU/ml; LH, 72 +/- 19 mlU/ml) and E2 (19 +/- 8 pg/ml). Two additional women (ages 21 and 39 yr) who received radiation (7,000 rad) to the pelvis plus chemotherapy developed prompt cessation of menses and became functional castrates (FSH, 77 and 80 mlU/ml; LH, 40 and 58 mlU/ml; E2, 10 and 19 pg/ml). However, this result would be expected from the radiation dose alone. The data demonstrated that ovarian dysfunction may follow the use of doxorubicin, cyclophosphamide, and high doses of methotrexate and that the injury is age related.
- Research Organization:
- Surgery Branch, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health and Human Services, Bethesda, MD
- OSTI ID:
- 5475130
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Vol. 67:6
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMOTHERAPY
SIDE EFFECTS
RADIOTHERAPY
SARCOMAS
AGE DEPENDENCE
BIOLOGICAL RADIATION EFFECTS
DOXORUBICIN
ENDOXAN
ESTRADIOL
FSH
GONADOTROPINS
LH
MENSTRUATION DISORDERS
METHOTREXATE
OVARIES
PATIENTS
WOMEN
ALKYLATING AGENTS
ANIMALS
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ANTIBIOTICS
ANTIMETABOLITES
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BODY
DISEASES
DRUGS
ESTRANES
ESTROGENS
FEMALE GENITALS
FEMALES
GONADS
HORMONES
HYDROXY COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
RADIATION EFFECTS
RADIOLOGY
STEROID HORMONES
STEROIDS
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560151* - Radiation Effects on Animals- Man
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550600 - Medicine