Effects of biliary obstruction on hepatic clearance of bacteria

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Archives of Surgery (Chicago); (USA)

DOI:https://doi.org/10.1001/archsurg.1989.01410080109018· OSTI ID:5473516

Allen, M O; Wilton, P B; Barke, R A; Gerding, D N; Forstrom, L A; Shafer, R B; Vennes, J A ^[1]

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1. Veterans Administration Medical Center, Minneapolis, MN (USA)

High surgical mortality in patients with obstructive jaundice and sepsis have been attributed to reticuloendothelial system (RES) depression. The purpose of this study was to clarify the effects of mechanical biliary obstruction on RES clearance of pathogenic bacteria by comparing the phagocytic index (K) with the directly measured hepatic uptake of indium 111-labeled bacteria injected into the portal vein of normal dogs and dogs with partial (PBO) or complete biliary obstruction (CBO). No significant difference was observed between the K in normal dogs (0.19 +/- 0.08; n = 6) and that in dogs with PBO (0.24 +/- 0.06; n = 5) or CBO (0.21 +/- 0.03; n = 4). There was no significant difference in uptake of radiolabel by the liver among the three groups of dogs. In our model, biliary obstruction had no effect on hepatic RES function and may not represent a significant determinant of mortality in patients with obstructive jaundice.

• OSTI ID: 5473516
• Journal Information: Archives of Surgery (Chicago); (USA), Vol. 124:8; ISSN 0004-0010
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DIGESTIVE SYSTEM DISEASES
BIOLOGICAL EFFECTS
PSEUDOMONAS
CLEARANCE
RETICULOENDOTHELIAL SYSTEM
BIOLOGICAL FUNCTIONS
ALKALINE PHOSPHATASE
BILIRUBIN
DOGS
INDIUM 111
LIVER
PHAGOCYTOSIS
SEPTICEMIA
TRACER TECHNIQUES
WEIGHT
ANIMAL TISSUES
ANIMALS
AZOLES
BACTERIA
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
ESTERASES
FUNCTIONS
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PHOSPHATASES
PIGMENTS
PYRROLES
RADIOISOTOPES
TISSUES
VERTEBRATES
550901* - Pathology- Tracer Techniques