Loss of calcitonin receptors: A genetically transmitted defect in rats with high incidence of C-cell tumors

Journal Article · Fri Sep 15 00:00:00 EDT 1989 · Cancer Research; (USA)

OSTI ID:5471906

Bouizar, Z; Minvielle, S; Treilhou-Lahille, F; Rostene, W H; Pidoux, E; Feingold, N; Milhaud, G; Moukhtar, M S ^[1]

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1. UA 163 CNRS and U.113 INSERM, Paris (France)

C-cell tumors (medullary thyroid carcinoma) occur in humans and several other mammalian species. This tumor develops spontaneously with a high incidence (50%) in old Wag/Rij (Wistar-derived strain) rats. We have recently shown that calcitonin binding sites, which are present in the Wistar rats, are lost from renal medulla of the Wag/Rij rats before they reach the age of 1 month. In the present work, we investigated the distribution of calcitonin binding sites in the kidneys of first and second generation hybrids of Wistar x Wag/Rij rats. The absence of calcitonin binding sites from the renal medullas of 25% of F2 hybrids indicates that the deficiency is inherited in a Mendelian fashion and opens the way to establishing inbred strains lacking renal medullary calcitonin binding sites.

• OSTI ID: 5471906
• Journal Information: Cancer Research; (USA), Vol. 49:18; ISSN 0008-5472
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CALCITONIN
RECEPTORS
THYROID
CARCINOMAS
AGE DEPENDENCE
AUTORADIOGRAPHY
CALCIUM
CHROMOSOMES
DISEASE INCIDENCE
GENETIC VARIABILITY
IODINE ISOTOPES
KIDNEYS
RATS
SPONTANEOUS MUTATIONS
TUMOR CELLS
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BIOLOGICAL VARIABILITY
BODY
DISEASES
ELEMENTS
ENDOCRINE GLANDS
GLANDS
HORMONES
ISOTOPES
MAMMALS
MEMBRANE PROTEINS
METALS
MUTATIONS
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
RODENTS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
550901 - Pathology- Tracer Techniques