Fate and residues of trenbolone acetate in edible tissues from sheep amd calves implanted with tritium-labeled trenbolone acetate

Journal Article · Thu Jun 01 00:00:00 EDT 1989 · Journal of Animal Science; (USA)

OSTI ID:5471473

Evrard, P; Maghuin-Rogister, G; Rico, A G ^[1]

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1. Univ. of Liege (Belgium)

In order to study the fate and residues of trenbolone acetate in edible tissues, two groups of six animals from two ruminant species (ewes and calves) were implanted with (3H)trenbolone acetate. The distribution of extractable radioactive residues was measured in liver, kidney and muscle. We found that the largest proportion of residues was not extractable and thus was considered as covalently bound residues. The proportion of the main extractable metabolites (17 alpha-trenbolone, trendione, 17 beta-trenbolone) was measured. The evaluation of the distribution of trenbolone acetate metabolites directly soluble in water showed that unknown metabolite(s) were predominant. The covalent binding to nucleic acids was measured. It was so low that it was not detectable. The results are discussed in light of the data presented in the scientific report on anabolic agents in animal production from the European scientific working group.

• OSTI ID: 5471473
• Journal Information: Journal of Animal Science; (USA), Vol. 67:6; ISSN 0021-8812
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
STEROIDS
METABOLISM
CATTLE
MEAT
RESIDUES
SHEEP
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
DISTRIBUTION
DOMESTIC ANIMALS
FOOD
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
ORGANIC COMPOUNDS
RUMINANTS
VERTEBRATES
550501* - Metabolism- Tracer Techniques