The effects of lidoflazine on exercise performance and thallium stress scintigraphy in patients with stable angina pectoris
Lidoflazine is a synthetic drug with calcium-channel blocking effects. In a 7-month study, 36 patients with stable angina pectoris were tested during a 3-month single-blind placebo phase. Nineteen were then randomized by double-blind methods to lidoflazine and 17 to placebo therapy. The lidoflazine group had a significant (p less than 0.01) reduction in anginal attacks; the placebo group did not. Exercise testing demonstrated that lidoflazine therapy was associated with a 34% increase in total work performance and a 15.6% increase in peak calculated oxygen uptake during double-blind treatment (both p less than 0.004 compared with the placebo group). Heart rate was significantly reduced at submaximal levels of exercise during lidoflazine therapy (p less than 0.04). Nitroglycerin consumption and electrocardiographic changes at the end of exercise did not change during the double-blind phase. In a second study of six similar patients, single-blind administration of lidoflazine was associated with improved myocardial perfusion during exercise as determined by thallium-201 stress scintigraphy. These studies demonstrate that lidoflazine therapy is associated with relief of angina, an increased physical work capacity, and improved regional myocardial perfusion during exercise.
- Research Organization:
- Cardiovascular Section, Medical Service, Veterans Administration Medical Center, Dallas, Texas
- OSTI ID:
- 5466417
- Journal Information:
- Circulation; (United States), Vol. 65:1 Pt 2
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CARDIOVASCULAR DISEASES
THERAPY
HEART
DYNAMIC FUNCTION STUDIES
SCINTISCANNING
BIOLOGICAL EFFECTS
CALCIUM
DRUGS
ELECTROCARDIOGRAMS
EXERCISE
MEMBRANE TRANSPORT
NITROGLYCERIN
PATIENTS
THALLIUM 201
ALKALINE EARTH METALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CHEMICAL EXPLOSIVES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGRAMS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ESTERS
EXPLOSIVES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALS
NITRIC ACID ESTERS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques