Adjuvant intraperitoneal chromic phosphate therapy for women with apparent early ovarian carcinoma who have not undergone comprehensive surgical staging
- Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC (USA)
Forty-nine women with apparent Stage 1 and 2 ovarian carcinoma received intraperitoneal phosphate 32 as the only adjuvant therapy after primary surgery. In addition to bilateral salpingo-oophorectomy, 40 (82%) had analysis of peritoneal cytology, and 35 (71%) underwent omentectomy. Random peritoneal biopsies and retroperitoneal lymph node sampling were not done in any of these patients. The overall and disease-free survival rates were 86% and 75%, respectively, with no significant differences by stage, histologic grade, histologic type, or low-risk versus high-risk subsets recognized in patients who received comprehensive surgical staging. Seven (58%) of 12 patients had lymph node metastasis as the first site of recurrence, including two of three with late recurrences. Significant morbidity related to intraperitoneal chromic phosphate (32P) occurred in one (2%) woman. These results emphasize the need for comprehensive surgical staging of women with apparent early ovarian carcinoma to aid in the selection of appropriate initial adjuvant therapy.
- OSTI ID:
- 5460573
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 68:4; ISSN 0008-543X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOMAS
RADIOTHERAPY
OVARIES
PATIENTS
PERITONEUM
PHOSPHATES
PHOSPHORUS 32
SURVIVAL CURVES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DISEASES
FEMALE GENITALS
GONADS
ISOTOPES
LIGHT NUCLEI
MEDICINE
MEMBRANES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHORUS COMPOUNDS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RADIOLOGY
SEROUS MEMBRANES
THERAPY
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)