Radioprotection of mice with interleukin-1: Relationship to the number of erythroid and granulocyte-macrophage colony-forming cells
This report presents the results of an investigation of changes in the number of erythroid and granulocyte-macrophage colony forming cells (GM-CFC) that had occurred in tissues of normal B6D2F1 mice 20 h after administration of a radioprotective dose (150 ng) of human recombinant interleukin-1 (rIL-1). Neutrophilia in the peripheral blood and changes in the tissue distribution of GM-CFC demonstrated that cells were mobilized from the bone marrow in response to rIL-1 injection. For example, 20 h after rIL-1 injection marrow GM-CFC numbers were 80% of the numbers in bone marrow from saline-injected mice. Associated with this decrease there was a twofold increase in the number of peripheral blood and splenic GM-CFC. Also, as determined by hydroxyurea injection, there was an increase in the number of GM-CFC in S phase of the cell cycle in the spleen, but not in the bone marrow. Data in this report suggest that when compared to the spleen, stimulation of granulopoiesis after rIL-1 injection is delayed in the bone marrow.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
- OSTI ID:
- 5459358
- Report Number(s):
- AD-A-235471/0/XAB; AFRRI-SR-91-21
- Country of Publication:
- United States
- Language:
- English
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LYMPHOKINES
RADIOSENSITIVITY EFFECTS
MACROPHAGES
TISSUE DISTRIBUTION
BONE MARROW
CELL CYCLE
COLONY FORMATION
ERYTHROCYTES
HYDROXYUREA
MICE
PHAGOCYTES
RETICULOENDOTHELIAL SYSTEM
SPLEEN
AMIDES
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISTRIBUTION
GROWTH FACTORS
HEMATOPOIETIC SYSTEM
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
MITOGENS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
RODENTS
SOMATIC CELLS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals