Exposure of humans to ambient levels of ozone for 6. 6 hours causes cellular and biochemical changes in the lung
An acute (2h) exposure of humans to 0.4 ppm ozone initiates biochemical changes in the lung resulting in the production of components which mediate inflammation and acute lung damage as well as components which have the potential to lead to long term effects such as fibrosis. However, many people are exposed to lower levels of ozone than this, but for periods of several hours. Therefore, it is important to determine if a prolonged exposure to low levels of ozone is also capable of causing cellular and biochemical changes in the lung. Non-smoking males were randomly exposed to filtered air and either 0.10 ppm ozone or 0.08 ppm ozone for 6.6 h with moderate exercise (40 1/min). Bronchalveolar lavage (BAL) was performed 18 h after each exposure, and cells and fluid analyzed. The BAL fluid of volunteers exposed to 0.10 ppm ozone had significant increases in neutrophils (PMNs), protein, PGE2, fibronectin, interleukin-6 (IL-6), and lactate dehydrogenase (LDH) compared with BAL fluid from the same volunteers exposed to filtered air. The study concludes that exposure of humans to low levels of ozone is sufficient to initiate an inflammatory reaction in the lung.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (United States). Health Effects Research Lab.
- OSTI ID:
- 5458604
- Report Number(s):
- PB-91-207126/XAB
- Resource Relation:
- Other Information: Pub. in American Jnl. of Respiratory, Cellular, and Molecular Biology, v4 p72-81 Jan 91. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Medicine, and ABB Environmental Services, Inc., Chapel Hill, NC
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
LUNGS
SENSITIVITY
OZONE
TOXICITY
ACUTE EXPOSURE
INFLAMMATION
LACTATE DEHYDROGENASE
LAVAGE
MAN
NEUTROPHILS
PHAGOCYTOSIS
PROTEINS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
ENZYMES
HEMIACETAL DEHYDROGENASES
LEUKOCYTES
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PATHOLOGICAL CHANGES
PRIMATES
RESPIRATORY SYSTEM
SYMPTOMS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology