Endurance running program reverses the age related declines in peak oxygen consumption
This study was designed to determine whether aging per se produces a decline in peak oxygen consumption (peak VO/sub 2/) or whether that decline may be due to the documented reduction in spontaneous activity. Male F344 rats, at the initial ages of 4 and 18 mos. of age, were divided into trained and untrained groups (YUT, YT, OUT, and OT). The trained groups ran up to 60 min/day 5 days/wk at a speed of 20m/min for 6 mos. The OUT rats demonstrated a 12% decline in peak VO/sub 2/ when compared to YUT rats. The OT rats had the same peak VO/sub 2/ as the YUT, but a 13% lower peak VO/sub 2/ than the YT. Representative enzymes of the TCA cycle, B oxidation, and electron transport system from gastrocnemius homogenates all declined in the OUT compared to YUT (14 to 24%). /sup 14/C-palmitate oxidation declined 45% in the OUT gastrocnemius compared to YUT. The carnitine values of the OUT were not significantly lower than the YUT and could not account for the large depression in palmitate oxidation. In contrast to the peak VO/sub 2/ which increased in OT only up to YUT values, the oxidative capacity of the skeletal muscle of OT was increased above the YUT group values equal to those of YT.
- Research Organization:
- Univ. of Texas, Austin
- OSTI ID:
- 5453326
- Report Number(s):
- CONF-8604222-; TRN: 86-026605
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
AGING
BIOLOGICAL EFFECTS
OXYGEN
BIOSYNTHESIS
AGE DEPENDENCE
CARBON 14 COMPOUNDS
EXERCISE
HEXADECANOIC ACID
RATS
TRACER TECHNIQUES
ANIMALS
CARBOXYLIC ACIDS
ELEMENTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONOCARBOXYLIC ACIDS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RODENTS
SYNTHESIS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques