Relationship between /sup 31/P nuclear magnetic resonance spectra and pulmonary vasomotor tone in hypoxic pig lobes
To investigate the relationship between lung tissue energy state and vasomotor tone, the authors measured /sup 31/P NMR spectra during repeated exposures to hypoxia in 5 isolated degassed left lower lobes perfused with blood at a constant flow (500ml/min) and left atrial pressure (<0mmHg). Perfusate O/sub 2/ tension (PpO/sub 2/) was changed by varying the gas mixtures (40, 7, 0% O/sub 2/) flowing through a bubble oxygenator in the perfusion circuit. /sup 31/P spectra obtained after stabilization of pulmonary artery pressure (Ppa) at each PpO/sub 2/ revealed peaks for ATP, inorganic phosphate (Pi) phosphomono and diesters (PME and PDE). During 7% O/sub 2/, Ppa and ATP increased but Pi did not change suggesting that lung tissue energy state improved during hypoxic vasoconstriction. During 0% O/sub 2/, there was a reversible deterioration of energy state (high Pi, low ATP). Thus, it appears that lung tissue energy state and vasomotor tone were related, but the precise nature of the relationship remains to be determined.
- Research Organization:
- Johns Hopkins Medical Institute, Baltimore, MD
- OSTI ID:
- 5449937
- Report Number(s):
- CONF-8604222-; TRN: 86-028444
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
LUNGS
BLOOD CIRCULATION
ANOXIA
ATP
BLOOD PRESSURE
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
PERFUSED ORGANS
PHOSPHORUS 31
SWINE
VASOCONSTRICTION
ANIMALS
BODY
DOMESTIC ANIMALS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
NUCLEI
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHOSPHORUS ISOTOPES
RESONANCE
RESPIRATORY SYSTEM
SPECTRA
STABLE ISOTOPES
VERTEBRATES
550600* - Medicine
551001 - Physiological Systems- Tracer Techniques