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Title: Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine

Abstract

This study analyzes the changes induced by subarachnoid hemorrhage (SAH) on the contractile responses and the noradrenaline release evoked in cat cerebral arteries by histamine. The dose-dependent vasoconstriction induced by histamine on the cerebral arteries of normal cats was significantly reduced by diphenhydramine and phentolamine. When SAH was produced 3 and 7 days before the experiment, the histamine-induced vasoconstriction also decreased. Thereafter, a tendency to normalization in the contractile vascular responses was observed such that in 15 days after the hemorrhage it was not significantly different from that found in controls animals. The decrease in the contractile responses to histamine provoked by SAH was similar to that seen after pretreatment with intracisternal injections of 6-hydroxydopamine. The amount of radioactivity released by histamine following preincubation with /sup 3/H-noradrenaline from the cerebral arteries of cats exposed to SAH 3, 7, and 15 days before the experiment was significantly reduced when compared with controls. Moreover, the basal level of tritium release and the radioactivity retained at the end of the experiment were also decreased after SAH. Results indicate histamine releases noradrenaline from cat cerebral arteries, and SAH produce a transient denervation of the perivascular adrenergic nerve endings, which explained by the impairment ofmore » the indirect adrenergic mechanism involved in the overall contractile response elicited by this amine in cerebral arteries. Histamine does not seem to play a significant role in the production of the cerebral vasospasm occurring after SAH.« less

Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5449389
Resource Type:
Journal Article
Journal Name:
J. Neurosurg.; (United States)
Additional Journal Information:
Journal Volume: 55:4
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; HEMORRHAGE; PATHOLOGY; HISTAMINE; BIOCHEMICAL REACTION KINETICS; NORADRENALINE; TRITIUM COMPOUNDS; ISOTOPE APPLICATIONS; ARTERIES; CATS; CEREBRUM; VASOCONSTRICTION; ADRENAL HORMONES; AMINES; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZOLES; BLOOD VESSELS; BODY; BRAIN; CARDIOTONICS; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DRUGS; HETEROCYCLIC COMPOUNDS; HORMONES; IMIDAZOLES; KINETICS; LABELLED COMPOUNDS; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; REACTION KINETICS; STEROID HORMONES; SYMPATHOMIMETICS; SYMPTOMS; VERTEBRATES; 550901* - Pathology- Tracer Techniques; 550201 - Biochemistry- Tracer Techniques

Citation Formats

Lobato, R D, Marin, J, Salaices, M, Rico, M L, and Sanchez, C F. Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine. United States: N. p., 1981. Web. doi:10.3171/jns.1981.55.4.0543.
Lobato, R D, Marin, J, Salaices, M, Rico, M L, & Sanchez, C F. Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine. United States. https://doi.org/10.3171/jns.1981.55.4.0543
Lobato, R D, Marin, J, Salaices, M, Rico, M L, and Sanchez, C F. 1981. "Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine". United States. https://doi.org/10.3171/jns.1981.55.4.0543.
@article{osti_5449389,
title = {Effect of subarachnoid hemorrhage on contractile responses and noradrenaline release evoked in cat cerebral arteries by histamine},
author = {Lobato, R D and Marin, J and Salaices, M and Rico, M L and Sanchez, C F},
abstractNote = {This study analyzes the changes induced by subarachnoid hemorrhage (SAH) on the contractile responses and the noradrenaline release evoked in cat cerebral arteries by histamine. The dose-dependent vasoconstriction induced by histamine on the cerebral arteries of normal cats was significantly reduced by diphenhydramine and phentolamine. When SAH was produced 3 and 7 days before the experiment, the histamine-induced vasoconstriction also decreased. Thereafter, a tendency to normalization in the contractile vascular responses was observed such that in 15 days after the hemorrhage it was not significantly different from that found in controls animals. The decrease in the contractile responses to histamine provoked by SAH was similar to that seen after pretreatment with intracisternal injections of 6-hydroxydopamine. The amount of radioactivity released by histamine following preincubation with /sup 3/H-noradrenaline from the cerebral arteries of cats exposed to SAH 3, 7, and 15 days before the experiment was significantly reduced when compared with controls. Moreover, the basal level of tritium release and the radioactivity retained at the end of the experiment were also decreased after SAH. Results indicate histamine releases noradrenaline from cat cerebral arteries, and SAH produce a transient denervation of the perivascular adrenergic nerve endings, which explained by the impairment of the indirect adrenergic mechanism involved in the overall contractile response elicited by this amine in cerebral arteries. Histamine does not seem to play a significant role in the production of the cerebral vasospasm occurring after SAH.},
doi = {10.3171/jns.1981.55.4.0543},
url = {https://www.osti.gov/biblio/5449389}, journal = {J. Neurosurg.; (United States)},
number = ,
volume = 55:4,
place = {United States},
year = {Thu Oct 01 00:00:00 EDT 1981},
month = {Thu Oct 01 00:00:00 EDT 1981}
}