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Title: Combined therapy of septicemia with ofloxacin and/or synthetic trehalose dicorynomycolate (S-TDCM) in irradiated and wounded mice (kombinierte therapie der septikaemie mit ofloxacin und/oder synthetischem trehalose-dicorynomycolat (s-tdcm) bei bestrahlten und verwundeten maeusen)

Following lethal irradiation, mice usually succumb to sepsis as a result of translocation of intestinal bacteria and impairment of the host defense system. Additional trauma in these immunocompromised mice further increases susceptibility to bacterial infection from either endogenous or exogenous origin. Treatment with ofloxacin or synthetic trehalose dicorynemycolate (S-TDCM) was evaluated in mice, which were lethally irradiated and wounded, and which died with sepsis within six days. Wounding was performed on C3H/HeN mice anesthetized by inhalation of methoxyfurane. Dorsal skin and muscle equal to 30% total body surface was removed 1 h after 8.0 Gy gamma radiation. S-TDCM, which augments nonspecific resistance to infection in irradiated mice, was given once i.p. immediately after wounding. Oxfloxacin was injected s.c. daily from day 0 to day 10. Staphylococcus aureus, Streptococcus faecium, and Escherichia coli were isolated from both the livers and wound sites of moribund, untreated mice 4 and 5 days postirradiation.
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5448508
Report Number(s):
AD-A-235385/2/XAB; AFRRI-SR--91-14
Resource Type:
Technical Report
Research Org:
Armed Forces Radiobiology Research Inst., Bethesda, MD (United States)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BACTERIAL DISEASES; CHEMOTHERAPY; RETICULOENDOTHELIAL SYSTEM; BIOLOGICAL RADIATION EFFECTS; ESCHERICHIA COLI; GAMMA RADIATION; INFECTIOUS DISEASES; LETHAL IRRADIATION; LIVER; MICE; SEPTICEMIA; STAPHYLOCOCCUS; STREPTOCOCCUS; WOUNDS; ANIMAL TISSUES; ANIMALS; BACTERIA; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; ELECTROMAGNETIC RADIATION; GLANDS; INJURIES; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MICROORGANISMS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; THERAPY; TISSUES; VERTEBRATES 560152* -- Radiation Effects on Animals-- Animals