Immune response to Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5448223

Marsh, D G; Freidhoff, L R; Bias, W B; Roebber, M

Ultra-pure short ragweed pollen allergen Amb a VI (Ra6), mol. wt. 11,500 daltons, was used to explore the relationship between HLA-DR and specific immune responsiveness in 115 Caucasian subjects who were skin-test positive to short ragweed or 5 other common inhalant allergens. Immune responsiveness to Amb a VI was assessed by measuring IgE and IgG antibodies (Abs) by double Ab radioimmunoassay. A striking and significant association was found between IgEAb responsiveness to Amb a VI and the possession of HLA-DR5: 13/16 (81%) of responders vs. 12/99 (12%) of non-responders were DR5+ (p = 8 x 10/sup -8/). The association with IgGAb responsiveness was less striking (p = 0.003). These results add to the growing body of evidence that studies using ultra-pure allergens provide valuable insight into the genetic basis of human immune responsiveness.

• Research Organization: Johns Hopkins USM, Baltimore, MD
• OSTI ID: 5448223
• Report Number(s): CONF-8604222-; TRN: 86-028543
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

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