Synthesis of 14C-labeled perfluorooctanoic and perfluorodecanoic acids; Purification of perfluorodecanoic acid

Technical Report · Thu Jan 01 00:00:00 EST 1987

OSTI ID:5447428

Reich, I L; Reich, H J; Menahan, L A; Peterson, R E

Perfluorooctanoic and -decanoic acids are representative of a series of perfluorinated acids that have been used for a variety of industrial purposes primarily due to their surfactant properties. The toxicity of these compounds is being investigated in a number of laboratories. 14C-labeled materials would be useful in these studies but are not commercially available. Johncock prepared unlabeled PFOA in low yield by carbonation of the unstable perfluoroheptyllithium at -90 degrees Centigrade. We anticipated several problems in applying this procedure to the synthesis of the 14C-labeled material. Johncock's procedure was run on a fairly large scale (10 mmol) with excess CO2.

• Research Organization: Wisconsin Univ., Madison, WI (United States)
• OSTI ID: 5447428
• Report Number(s): AD-A-234684/9/XAB; CNN: AFOSR-85-0207
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
OCTANOIC ACID
CHEMICAL PREPARATION
TOXICITY
CARBON 14 COMPOUNDS
CARBONATES
FLUORINATION
PURIFICATION
SURFACTANTS
TRACER TECHNIQUES
CARBON COMPOUNDS
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
HALOGENATION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
SYNTHESIS
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques