Effects of prenatal exposure to 2,4-D/2,4,5-T mixture on postnatal changes in rat brain glutamate, GABA protein, and nucleic acid levels
The opportunity of maternal exposure to various chemicals in the work place and the general environments have increased, and the fetus and neonate may be at greater risk than the adult. However, the embryotoxic and teratogenic effects of the chlorinated phenoxy herbicides 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), the main chemicals in Agent Orange, are well documented only in laboratory animals. The brain of the developing fetus is vulnerable to the toxic effects of the phenoxy herbicides which readily cross the placental barrier and distribute into fetal tissues, including brain. Although the neurochemical basis for the behavioral teratogenicity of the phenoxy herbicides is not know, it was recently reported that non-teratogenic doses of a 1:1 mixture of 2,4-D and 2,4,5-T delayed the ontogeny of dopamine and serotonin in the brain of the developing rate. This communication provides further descriptive information about the ontogeny of rat brain nucleic acid, protein, glutamate and ..gamma..-aminobutyrate (GABA) following in utero exposure to non-teratogenic levels of a 1:1 mixture of 2,4-D/2,4,5-T.
- Research Organization:
- Univ. of Missouri, Columbia
- OSTI ID:
- 5440067
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 40:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
BIOCHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
PRENATAL EXPOSURE
AMINOBUTYRIC ACID
DNA
GLUTAMIC ACID
HERBICIDES
PREGNANCY
PROTEINS
RATS
RNA
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DRUGS
HALOGENATED ALIPHATIC HYDROCARBONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology