Fast neutrons and misonidazole for malignant astrocytomas

Journal Article · Mon Apr 01 00:00:00 EST 1985 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(85)90298-6· OSTI ID:5436470

Kurup, P D; Pajak, T F; Hendrickson, F R; Nelson, J S; Mansell, J; Cohen, L; Awschalom, M; Rosenberg, I; Ten Haken, R K

Twenty-five patients with proven malignant supratentorial astrocytomas were entered into a Phase I/II study of misonidazole combined with neutron radiation at Fermilab Neutron Therapy Facility (NTF) between August 1979 and April 1981. The main objectives were to determine tissue tolerance in terms of acute and late effects, and to estimate tumor clearance and survival rates. The total dose was 18.0 Gy given in weekly fractions of 3.0 Gy over 39 days. Four hours before each irradiation, 2.5 gm/m/sup 2/ misonidazole was administered orally. The median survival for the whole group was 12.0 months; 25% were alive at 18 months with some neurological compromise. Acute toxicity was within tolerable limits. Details of toxicity and tissue analysis from post mortems and second craniotomy samples are presented.

• Research Organization: Fermilab Neutron Therapy Facility, Batavia, IL
• OSTI ID: 5436470
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 11:4
• Country of Publication: United States
• Language: English

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