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Title: Cardiovascular and endocrine response to hemorrhage after. cap alpha. /sub 1/-blockade in lambs and ewes

To evaluate the role of the ..cap alpha../sub 1/-adrenergic system in the response to hemorrhage during development, lambs and adult sheep were chronically catheterized and hemorrhaged after pretreatment with prazosin or vehicle. The adults became markedly more hypotensive after ..cap alpha../sub 1/-blockade and hemorrhage than after vehicle and hemorrhage, whereas the lambs were no more hypotensive when hemorrhaged after prazosin. In the adults and the lambs hemorrhage produced elevations in plasma renin activity and arginine vasopressin measured by radioimmunoassay. However, after prazosin, the adults had a far greater increase in arginine vasopressin levels than after vehicle treatment.
Authors:
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Publication Date:
OSTI Identifier:
5434690
Resource Type:
Journal Article
Resource Relation:
Journal Name: Am. J. Physiol.; (United States); Journal Volume: 252:2
Research Org:
Wake Forest Univ., Winston-Salem, NC
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEMORRHAGE; PHYSIOLOGY; RENIN; RADIOIMMUNOASSAY; VASOPRESSIN; AGE DEPENDENCE; ANGIOTENSIN; BLOOD PRESSURE; ENDOCRINE GLANDS; ENZYME ACTIVITY; HOMEOSTASIS; SHEEP; ANIMALS; BODY; CARDIOVASCULAR AGENTS; DOMESTIC ANIMALS; DRUGS; ENZYMES; GLANDS; GLOBULINS; HORMONES; HYDROLASES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; NONSPECIFIC PEPTIDASES; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; PEPTIDE HYDROLASES; PITUITARY HORMONES; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RUMINANTS; SYMPTOMS; TRACER TECHNIQUES; VASOCONSTRICTORS; VERTEBRATES 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics