Effect of dietary tyrosine supplementation on development of deoxycorticosterone acetate (DOCA)-induced hypertension in rats

Conference · Sat Mar 01 00:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5434268

Henley, W N; Fregly, M J; Mihally, M A; Wilson, K M; Hathaway, S

Adult male Sprague-Dawley rats were unilaterally nephrectomized, given 0.15M NaCl to drink, and assigned to 1 or 4 groups: (a) control diet (CD); (b) CD plus DOCA (39 ..mu..g/rat/day); (c) CD supplemented with 2.5% 1-tyrosine (Tyr); and (d) Tyr plus DOCA. DOCA significantly elevated systolic blood pressure (SBP) within 2 weeks (P < 0.05); however, Tyr for 8 weeks failed to affect SBP. Direct measurement of BP confirmed these findings. Tyrosine also failed to affect the enhanced vascular reactivity (change in MBP to phenylephrine) noted in DOCA-treated rats. Although ineffective in these regards, Tyr alone induced both significant elevations in urinary excretion of free dopamine (week 1, 3, 5, 7) and a significant decrease in urinary free norepinephrine excretion (week 1). Tyr induced significant prolongations in the time-courses of metabolic and cardiovascular responses to the beta-adrenergic agonist, isoproterenol. The binding (B/sub max/) of /sup 3/H-yohimbine in cerebral cortical membranes was also reduced. Thus, chronic excess of precursor can affect the function of the adrenergic system, but these effects do not include mitigation of DOCA-salt hypertension.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 5434268
• Report Number(s): CONF-8604222-; TRN: 86-026706
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
DOCA
BIOLOGICAL EFFECTS
HYPERTENSION
PATHOGENESIS
TYROSINE
BLOOD PRESSURE
CELL MEMBRANES
DIET
DOPAMINE
EXCRETION
NEPHRECTOMY
NORADRENALINE
PRECURSOR
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ADRENAL HORMONES
AMINES
AMINO ACIDS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CELL CONSTITUENTS
CLEARANCE
CORTICOSTEROIDS
DISEASES
DRUGS
HORMONES
HYDROXY ACIDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MEMBRANES
MINERALOCORTICOIDS
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PREGNANES
RODENTS
STEROID HORMONES
STEROIDS
SURGERY
SYMPATHOMIMETICS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
550901* - Pathology- Tracer Techniques