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Title: Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis

Abstract

Heart disease in patients with progressive systemic sclerosis may be due in part to myocardial ischemia caused by a disturbance of the coronary microcirculation. To determine whether abnormalities of myocardial perfusion in this disorder are potentially reversible, we evaluated the effect of the coronary vasodilator nifedipine on myocardial perfusion assessed by thallium-201 scanning in 20 patients. Thallium-201 single-photon-emission computerized tomography was performed under control conditions and 90 minutes after 20 mg of oral nifedipine. The mean (+/- SD) number of left ventricular segments with perfusion defects decreased from 5.3 +/- 2.0 to 3.3 +/- 2.2 after nifedipine (P = 0.0003). Perfusion abnormalities were quantified by a perfusion score (0 to 2.0) assigned to each left ventricular segment and by a global perfusion score (0 to 18) for the entire left ventricle. The mean perfusion score in segments with resting defects increased from 0.97 +/- 0.24 to 1.26 +/- 0.44 after nifedipine (P less than 0.00001). The mean global perfusion score increased from 11.2 +/- 1.7 to 12.8 +/- 2.4 after nifedipine (P = 0.003). The global perfusion score increased by at least 2.0 in 10 patients and decreased by at least 2.0 in only 1. These observations reveal short-term improvementmore » in thallium-201 myocardial perfusion with nifedipine in patients with progressive systemic sclerosis. The results are consistent with a potentially reversible abnormality of coronary vasomotion in this disorder, but the long-term therapeutic effects of nifedipine remain to be determined.« less

Authors:
; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Rene Descartes Univ., Paris, France
OSTI Identifier:
5428824
Resource Type:
Journal Article
Journal Name:
N.Engl. J. Med.; (United States)
Additional Journal Information:
Journal Volume: 22
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CORONARIES; BLOOD CIRCULATION; MYOCARDIUM; ISCHEMIA; RADIOISOTOPE SCANNING; VASODILATORS; BIOLOGICAL EFFECTS; CARDIOVASCULAR DISEASES; PATIENTS; PERFUSED ORGANS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; THALLIUM 201; ARTERIES; BETA DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HEART; HEAVY NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; THALLIUM ISOTOPES; TOMOGRAPHY; VASCULAR DISEASES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Kahan, A, Devaux, J Y, Amor, B, Menkes, C J, Weber, S, Nitenberg, A, Venot, A, Guerin, F, Degeorges, M, and Roucayrol, J C. Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis. United States: N. p., 1986. Web. doi:10.1056/NEJM198605293142201.
Kahan, A, Devaux, J Y, Amor, B, Menkes, C J, Weber, S, Nitenberg, A, Venot, A, Guerin, F, Degeorges, M, & Roucayrol, J C. Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis. United States. https://doi.org/10.1056/NEJM198605293142201
Kahan, A, Devaux, J Y, Amor, B, Menkes, C J, Weber, S, Nitenberg, A, Venot, A, Guerin, F, Degeorges, M, and Roucayrol, J C. 1986. "Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis". United States. https://doi.org/10.1056/NEJM198605293142201.
@article{osti_5428824,
title = {Nifedipine and thallium-201 myocardial perfusion in progressive systemic sclerosis},
author = {Kahan, A and Devaux, J Y and Amor, B and Menkes, C J and Weber, S and Nitenberg, A and Venot, A and Guerin, F and Degeorges, M and Roucayrol, J C},
abstractNote = {Heart disease in patients with progressive systemic sclerosis may be due in part to myocardial ischemia caused by a disturbance of the coronary microcirculation. To determine whether abnormalities of myocardial perfusion in this disorder are potentially reversible, we evaluated the effect of the coronary vasodilator nifedipine on myocardial perfusion assessed by thallium-201 scanning in 20 patients. Thallium-201 single-photon-emission computerized tomography was performed under control conditions and 90 minutes after 20 mg of oral nifedipine. The mean (+/- SD) number of left ventricular segments with perfusion defects decreased from 5.3 +/- 2.0 to 3.3 +/- 2.2 after nifedipine (P = 0.0003). Perfusion abnormalities were quantified by a perfusion score (0 to 2.0) assigned to each left ventricular segment and by a global perfusion score (0 to 18) for the entire left ventricle. The mean perfusion score in segments with resting defects increased from 0.97 +/- 0.24 to 1.26 +/- 0.44 after nifedipine (P less than 0.00001). The mean global perfusion score increased from 11.2 +/- 1.7 to 12.8 +/- 2.4 after nifedipine (P = 0.003). The global perfusion score increased by at least 2.0 in 10 patients and decreased by at least 2.0 in only 1. These observations reveal short-term improvement in thallium-201 myocardial perfusion with nifedipine in patients with progressive systemic sclerosis. The results are consistent with a potentially reversible abnormality of coronary vasomotion in this disorder, but the long-term therapeutic effects of nifedipine remain to be determined.},
doi = {10.1056/NEJM198605293142201},
url = {https://www.osti.gov/biblio/5428824}, journal = {N.Engl. J. Med.; (United States)},
number = ,
volume = 22,
place = {United States},
year = {Thu May 29 00:00:00 EDT 1986},
month = {Thu May 29 00:00:00 EDT 1986}
}