Variation of lead-induced lethality in estradiol-treated mice
Studies were undertaken to test the female sex hormone ..beta..-estradiol for its ability to modify lethality in young adult female and male mice exposed to lead acetate. Mice were injected with ..beta..-estradiol on day -1 and 0, and immediately after the second injection lead acetate was administered at four subgroup dosages ranging from 75 to 600 mg/kg body weight. Control mice were injected with only lead acetate. On day 4, 6, and 8 after Pb, the median lethal dosages (LD/sub 50/s) were calculated from the observed mortality ratios by a method for moving averages. LD/sub 50/ values were considerably lower for the Pb- and ..beta..-estradiol-injected groups than for the controls. Data from these experiments indicate that the ..beta..-estradiol treatments render both female and male mice more vulnerable to the lethal effects of lead acetate.
- Research Organization:
- Purdue Univ., Fort Wayne, IN
- OSTI ID:
- 5425703
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Vol. 9:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Butyl paraben and propyl paraben modulate bisphenol A and estradiol concentrations in female and male mice
Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane
Related Subjects
ESTRADIOL
BIOLOGICAL EFFECTS
LEAD
TOXICITY
RESPONSE MODIFYING FACTORS
INJECTION
LETHAL DOSES
MICE
MORTALITY
SURVIVAL CURVES
ANIMALS
DOSES
ELEMENTS
ESTRANES
ESTROGENS
HORMONES
HYDROXY COMPOUNDS
INTAKE
MAMMALS
METALS
ORGANIC COMPOUNDS
RODENTS
STEROID HORMONES
STEROIDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)