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Title: Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981

Abstract

This progress report covers work done during the period July 1, 1980 to August 31, 1981, to study the effect of polynuclear aromatic hydrocarbons (PAH) on artificial membrane systems chosen to model lung surfactant. Such PAH compounds adsorbed on flyash particles from coal combustion are of interest since they or their metabolic byproducts could be potential carcinogens. Since the composition of organic material adsorbed on flyash from fluidized bed combustion (FBC) of coal was and still is not well characterized, we chose as a model compound 2,3-dihydroxynaphthalene (2,3DHN) to represent to some extent the following relevant properties of those PAH compounds that might be particularly effective in interacting with and penetrating lung surfactant: solubility in water; solubility in hydrocarbon liquids; and its amphipathic character. This study was to determine whether PAH compounds (1) are miscible with surfactant; (2) modify the membrane structure when miscible; (3) can be transported (and at what rate) across a membrane. The detailed exposition of the results is classified by the particular instrumental technique used to achieve these objectives: surface film pressure versus area measurements; visible, UV and fluorescence spectroscopy; proton and phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy. Efforts concentrated on the first of these techniques.more » 9 figs.« less

Authors:
Publication Date:
Research Org.:
State Univ. of New York, Buffalo (USA). Dept. of Chemistry
OSTI Identifier:
5414954
Report Number(s):
DOE/MC/14514-1796
ON: DE85003396
DOE Contract Number:  
AC21-80MC14514
Resource Type:
Technical Report
Resource Relation:
Other Information: Portions of this document are illegible in microfiche products. Original copy available until stock is exhausted
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 01 COAL, LIGNITE, AND PEAT; FLY ASH; TOXICITY; LUNGS; SURFACTANTS; POLYCYCLIC AROMATIC HYDROCARBONS; COAL; COMBUSTION PRODUCTS; MEMBRANES; PHYSIOLOGY; AEROSOL WASTES; AROMATICS; ASHES; BODY; CARBONACEOUS MATERIALS; ENERGY SOURCES; FOSSIL FUELS; FUELS; HYDROCARBONS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; RESIDUES; RESPIRATORY SYSTEM; WASTES; 560301* - Chemicals Metabolism & Toxicology- Cells- (-1987); 016000 - Coal, Lignite, & Peat- Health & Safety

Citation Formats

Kurland, R J. Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981. United States: N. p., 1985. Web.
Kurland, R J. Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981. United States.
Kurland, R J. 1985. "Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981". United States.
@article{osti_5414954,
title = {Studies of the effect of toxic coal particles on model membrane systems. Progress report, July 1, 1980-August 31, 1981},
author = {Kurland, R J},
abstractNote = {This progress report covers work done during the period July 1, 1980 to August 31, 1981, to study the effect of polynuclear aromatic hydrocarbons (PAH) on artificial membrane systems chosen to model lung surfactant. Such PAH compounds adsorbed on flyash particles from coal combustion are of interest since they or their metabolic byproducts could be potential carcinogens. Since the composition of organic material adsorbed on flyash from fluidized bed combustion (FBC) of coal was and still is not well characterized, we chose as a model compound 2,3-dihydroxynaphthalene (2,3DHN) to represent to some extent the following relevant properties of those PAH compounds that might be particularly effective in interacting with and penetrating lung surfactant: solubility in water; solubility in hydrocarbon liquids; and its amphipathic character. This study was to determine whether PAH compounds (1) are miscible with surfactant; (2) modify the membrane structure when miscible; (3) can be transported (and at what rate) across a membrane. The detailed exposition of the results is classified by the particular instrumental technique used to achieve these objectives: surface film pressure versus area measurements; visible, UV and fluorescence spectroscopy; proton and phosphorus-31 nuclear magnetic resonance (NMR) spectroscopy. Efforts concentrated on the first of these techniques. 9 figs.},
doi = {},
url = {https://www.osti.gov/biblio/5414954}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Apr 01 00:00:00 EST 1985},
month = {Mon Apr 01 00:00:00 EST 1985}
}

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