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Title: Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice

Abstract

The tissue distribution and excretion of (/sup 3/H)8-methoxypsoralen (8-MOP), a well-accepted therapeutic agent for the treatment of psoriasis, was studied in hairless HRA/Skh female mice. Mice were given single oral doses of 6 mg of (/sup 3/H)8-MOP or 5-(/sup 14/C)8-MOP/kg in corn oil. Radiochemical analyses of tissues and excreta were accomplished by liquid scintillation counting. The 8-MOP appeared to be rapidly absorbed through the gastrointestinal tract, where the tritium levels were highest, followed by skin, blood, and liver; levels were lowest in fat (adipose tissue). In female HRA/Skh mice which had not been irradiated with UVA (320-400 nm), 84% of the carbon-14 and 58% of the tritium were recovered in the urine and feces within 24 hours of oral administration of 5-(/sup 14/C)8-MOP or (/sup 3/H)8-MOP, respectively. Animals that were exposed to UVA and received (3H)8-MOP excreted approximately 12% less tritium in the urine and feces compared with the animals which received no UVA.

Authors:
; ; ;
Publication Date:
Research Org.:
Bioassay Systems Corp., Woburn, MA
OSTI Identifier:
5414391
Resource Type:
Journal Article
Journal Name:
Natl. Cancer Inst. Monogr.; (United States)
Additional Journal Information:
Journal Volume: 66
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; NEAR ULTRAVIOLET RADIATION; BIOLOGICAL EFFECTS; PSORALEN; RETENTION; TISSUE DISTRIBUTION; ADIPOSE TISSUE; BIOASSAY; BLOOD; CARBON 14 COMPOUNDS; FECES; GASTROINTESTINAL TRACT; LIQUID SCINTILLATORS; LIVER; MICE; SCINTILLATION COUNTING; SKIN; TRITIUM COMPOUNDS; URINE; ANIMAL TISSUES; ANIMALS; ANTICOAGULANTS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CONNECTIVE TISSUE; COUMARINS; COUNTING TECHNIQUES; DIGESTIVE SYSTEM; DISTRIBUTION; DRUGS; ELECTROMAGNETIC RADIATION; GLANDS; HEMATOLOGIC AGENTS; HETEROCYCLIC COMPOUNDS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PHOSPHORS; RADIATIONS; RODENTS; TISSUES; ULTRAVIOLET RADIATION; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 550501 - Metabolism- Tracer Techniques

Citation Formats

Muni, I A, Schneider, F H, Olsson, III, T A, and King, M. Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice. United States: N. p., 1984. Web.
Muni, I A, Schneider, F H, Olsson, III, T A, & King, M. Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice. United States.
Muni, I A, Schneider, F H, Olsson, III, T A, and King, M. 1984. "Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice". United States.
@article{osti_5414391,
title = {Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice},
author = {Muni, I A and Schneider, F H and Olsson, III, T A and King, M},
abstractNote = {The tissue distribution and excretion of (/sup 3/H)8-methoxypsoralen (8-MOP), a well-accepted therapeutic agent for the treatment of psoriasis, was studied in hairless HRA/Skh female mice. Mice were given single oral doses of 6 mg of (/sup 3/H)8-MOP or 5-(/sup 14/C)8-MOP/kg in corn oil. Radiochemical analyses of tissues and excreta were accomplished by liquid scintillation counting. The 8-MOP appeared to be rapidly absorbed through the gastrointestinal tract, where the tritium levels were highest, followed by skin, blood, and liver; levels were lowest in fat (adipose tissue). In female HRA/Skh mice which had not been irradiated with UVA (320-400 nm), 84% of the carbon-14 and 58% of the tritium were recovered in the urine and feces within 24 hours of oral administration of 5-(/sup 14/C)8-MOP or (/sup 3/H)8-MOP, respectively. Animals that were exposed to UVA and received (3H)8-MOP excreted approximately 12% less tritium in the urine and feces compared with the animals which received no UVA.},
doi = {},
url = {https://www.osti.gov/biblio/5414391}, journal = {Natl. Cancer Inst. Monogr.; (United States)},
number = ,
volume = 66,
place = {United States},
year = {Sat Dec 01 00:00:00 EST 1984},
month = {Sat Dec 01 00:00:00 EST 1984}
}