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Title: sup 111 In-labeled nonspecific immunoglobulin scanning in the detection of focal infection

We performed radionuclide scanning after the intravenous injection of human IgG labeled with indium-111 in 128 patients with suspected focal sites of inflammation. Localization of 111In-labeled IgG correlated with clinical findings in 51 infected patients (21 with abdominal or pelvic infections, 11 with intravascular infections, 7 with pulmonary infections, and 12 with skeletal infections). Infecting organisms included gram-positive bacteria, gram-negative bacteria, Pneumocystis carinii, Mycoplasma pneumoniae, and Candida albicans. No focal localization of 111In-labeled IgG was observed in 63 patients without infection. There were five false negative results, and nine results were unusable. Serial scans were carried out in eight patients: continued localization correctly predicted relapse in six, and the absence of localization indicated resolution in two. To determine whether 111In-labeled IgG localization was specific for inflammation, we studied 16 patients with cancer. Focal localization occurred in 13 of these patients (5 with melanomas, 5 with gynecologic cancers, and 1 each with lymphoma, prostate cancer, and malignant fibrous histiocytoma). No localization was seen in patients with renal or colon cancer or metastatic medullary carcinoma of the thyroid. We conclude that 111In-labeled IgG imaging is effective for the detection of focal infection and that serial scans may be useful in assessing therapeuticmore » efficacy. This technique may also be helpful in the evaluation of certain cancers.« less
Authors:
; ; ; ; ; ; ;  [1]
  1. (Massachusetts General Hospital, Boston (USA))
Publication Date:
OSTI Identifier:
5411169
Resource Type:
Journal Article
Resource Relation:
Journal Name: New England Journal of Medicine; (USA); Journal Volume: 321:14
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; IMMUNOGLOBULINS; BIOLOGICAL LOCALIZATION; INFECTIOUS DISEASES; DIAGNOSIS; NEOPLASMS; ACCURACY; BACTERIA; CANDIDA; INDIUM 111; INFLAMMATION; LABELLING; MAN; MYCOPLASMA; PATIENTS; RADIOISOTOPE SCANNING; ANIMALS; BETA DECAY RADIOISOTOPES; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EUMYCOTA; FUNGI; GLOBULINS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MICROORGANISMS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PATHOLOGICAL CHANGES; PLANTS; PRIMATES; PROTEINS; RADIOISOTOPES; SYMPTOMS; VERTEBRATES; YEASTS 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics