Simple analytical test and a formula to predict the potential for dermal carcinogenicity from petroleum oils

Journal Article · Sun Nov 01 00:00:00 EST 1987 · Am. Ind. Hyg. Assoc. J.; (United States)

DOI:https://doi.org/10.1080/15298668791385840· OSTI ID:5408668

Haas, J M; Dimeler, G R; Basil, E W; Wilkins, G W; Nutter, J S

A correlation for predicting dermal carcinogenicity of petroleum oils in laboratory animals has been developed using two simple analytical tests. The tests are the Food and Drug Administration test (FDA) commonly used to measure white oil purity, and a viscosity test. In the correlation, FDA is a measure of aromaticity, and viscosity is used to account for molecular weight. The FDA test alone appears to be comparable to other predictors now in use, but incorporating viscosity significantly increases the accuracy of predicting dermal carcinogenicity. A formula is proposed, using both the FDA test results and viscosity, that predicts the percentage of mice which will develop neoplastic skin tumors.

• Research Organization: Sun Refining and Marketing Co., Philadelphia, PA (USA)
• OSTI ID: 5408668
• Journal Information: Am. Ind. Hyg. Assoc. J.; (United States), Vol. 48:11
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PETROLEUM
CARCINOGENESIS
SKIN
NEOPLASMS
BIOLOGICAL MODELS
MEASURING METHODS
MICE
ANIMALS
BODY
DISEASES
ENERGY SOURCES
FOSSIL FUELS
FUELS
MAMMALS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
020600* - Petroleum- Health & Safety
560300 - Chemicals Metabolism & Toxicology