skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Antibody-mediated radiotherapy

Abstract

Antibodies that react with antigens on the surface of tumor cells but not normal cells have great potential for cancer detection and therapy. If radiolabeled without loss of immunologic specificity, such antibodies may be able to deliver cytoxic amounts of radiation. Target- cell specificity and a high extraction coefficient are necessary with any radionuclide in order to minimize normal tissue irradiation. Tumor- cell-retention time and the rate of catabolized radionuclide will also influence ultimate applicability. Among the unanswered questions for choosing a radionuclide is the choice of particle emitter. Although classic beta emitters have been used in a number of clinical situations, they have not had a major impact on disease outcome except in diseases of the thyroid. Unfortunately, Auger emitters such as iodine 125 are cytotoxic only when localized within close proximity to the genome. On the other hand, alpha emitters such as astatine 211 eliminate the need for subcellular sequestration but not cell-specific localization. 34 references.

Authors:
; ;
Publication Date:
Research Org.:
Mount Sinai Medical Center, New York, NY
OSTI Identifier:
5407606
Resource Type:
Journal Article
Journal Name:
Cancer (Philadelphia); (United States)
Additional Journal Information:
Journal Volume: 55:Suppl. 9
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; DIAGNOSIS; IMMUNOTHERAPY; RADIOTHERAPY; TUMOR CELLS; ANTIGEN-ANTIBODY REACTIONS; ALPHA PARTICLES; ANTIBODIES; ASTATINE 211; BETA PARTICLES; IODINE 125; ALPHA DECAY RADIOISOTOPES; ANIMAL CELLS; ASTATINE ISOTOPES; BETA DECAY RADIOISOTOPES; CHARGED PARTICLES; DAYS LIVING RADIOISOTOPES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; RADIOISOTOPES; RADIOLOGY; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 550601 - Medicine- Unsealed Radionuclides in Diagnostics

Citation Formats

Bloomer, W D, Lipsztein, R, and Dalton, J F. Antibody-mediated radiotherapy. United States: N. p., 1985. Web. doi:10.1002/1097-0142(19850501)55:9+<2229::AID-CNCR2820551427>3.0.CO;2-X.
Bloomer, W D, Lipsztein, R, & Dalton, J F. Antibody-mediated radiotherapy. United States. https://doi.org/10.1002/1097-0142(19850501)55:9+<2229::AID-CNCR2820551427>3.0.CO;2-X
Bloomer, W D, Lipsztein, R, and Dalton, J F. 1985. "Antibody-mediated radiotherapy". United States. https://doi.org/10.1002/1097-0142(19850501)55:9+<2229::AID-CNCR2820551427>3.0.CO;2-X.
@article{osti_5407606,
title = {Antibody-mediated radiotherapy},
author = {Bloomer, W D and Lipsztein, R and Dalton, J F},
abstractNote = {Antibodies that react with antigens on the surface of tumor cells but not normal cells have great potential for cancer detection and therapy. If radiolabeled without loss of immunologic specificity, such antibodies may be able to deliver cytoxic amounts of radiation. Target- cell specificity and a high extraction coefficient are necessary with any radionuclide in order to minimize normal tissue irradiation. Tumor- cell-retention time and the rate of catabolized radionuclide will also influence ultimate applicability. Among the unanswered questions for choosing a radionuclide is the choice of particle emitter. Although classic beta emitters have been used in a number of clinical situations, they have not had a major impact on disease outcome except in diseases of the thyroid. Unfortunately, Auger emitters such as iodine 125 are cytotoxic only when localized within close proximity to the genome. On the other hand, alpha emitters such as astatine 211 eliminate the need for subcellular sequestration but not cell-specific localization. 34 references.},
doi = {10.1002/1097-0142(19850501)55:9+<2229::AID-CNCR2820551427>3.0.CO;2-X},
url = {https://www.osti.gov/biblio/5407606}, journal = {Cancer (Philadelphia); (United States)},
number = ,
volume = 55:Suppl. 9,
place = {United States},
year = {Wed May 01 00:00:00 EDT 1985},
month = {Wed May 01 00:00:00 EDT 1985}
}