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Title: Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia

Abstract

Irradiation of the neonatal rat hippocampus reduces the proliferation of granule cells in the dentate gyrus and results in locomotor hyperactivity, behavioral preservation, and deficits on some learned tasks. In order to address the role of changes in stimulus salience and behavioral inhibition in animals with this type of brain damage, irradiated and normal rats were compared in their startle reactions to an acoustic stimulus. Irradiated rats startled with a consistently higher amplitude than control and were more likely to exhibit startle responses. These animals with hippocampal damage also failed to habituate to the startle stimulus and, under certain circumstances, showed potentiated startle responses after many tone presentations.

Authors:
;
Publication Date:
Research Org.:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
OSTI Identifier:
5405531
Report Number(s):
AD-A-211220/9/XAB; AFRRI-SR-89-20
Resource Type:
Technical Report
Resource Relation:
Other Information: Pub. in Experimental Brain Research, Vol. 75, 28-34(1989)
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HIPPOCAMPUS; BIOLOGICAL RADIATION EFFECTS; RATS; BEHAVIOR; ACOUSTICS; AMPLITUDES; ANIMALS; INFANTS; INHIBITION; IRRADIATION; PRESERVATION; REFLEXES; STIMULI; AGE GROUPS; BIOLOGICAL EFFECTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; CHILDREN; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Mickley, G A, and Ferguson, J L. Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia. United States: N. p., 1989. Web.
Mickley, G A, & Ferguson, J L. Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia. United States.
Mickley, G A, and Ferguson, J L. 1989. "Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia". United States.
@article{osti_5405531,
title = {Enhanced acoustic startle responding in rats with radiation-induced hippocampal granule cell hypoplasia},
author = {Mickley, G A and Ferguson, J L},
abstractNote = {Irradiation of the neonatal rat hippocampus reduces the proliferation of granule cells in the dentate gyrus and results in locomotor hyperactivity, behavioral preservation, and deficits on some learned tasks. In order to address the role of changes in stimulus salience and behavioral inhibition in animals with this type of brain damage, irradiated and normal rats were compared in their startle reactions to an acoustic stimulus. Irradiated rats startled with a consistently higher amplitude than control and were more likely to exhibit startle responses. These animals with hippocampal damage also failed to habituate to the startle stimulus and, under certain circumstances, showed potentiated startle responses after many tone presentations.},
doi = {},
url = {https://www.osti.gov/biblio/5405531}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Jan 01 00:00:00 EST 1989},
month = {Sun Jan 01 00:00:00 EST 1989}
}

Technical Report:
Other availability
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