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Title: Spontaneous perseverative turning in rats with radiation-induced hippocampal damage

Abstract

This study found a new behavioral correlate of lesions specific to the dentate granule cell layer of the hippocampus: spontaneous perseverative turning. Irradiation of a portion of the neonatal rat cerebral hemispheres produced hypoplasia of the granule cell layer of the hippocampal dentate gyrus while sparing the rest of the brain. Radiation-induced damage to the hippocampal formation caused rats placed in bowls to spontaneously turn in long, slow bouts without reversals. Irradiated subjects also exhibited other behaviors characteristic of hippocampal damage (e.g., perseveration in spontaneous exploration of the arms of a T-maze, retarded acquisition of a passive avoidance task, and increased horizontal locomotion). These data extend previously reported behavioral correlates of fascia dentata lesions and suggest the usefulness of a bout analysis of spontaneous bowl turning as a measure of nondiscrete-trial spontaneous alternation and a sensitive additional indicator of radiation-induced hippocampal damage.

Authors:
; ; ; ;  [1]
  1. Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
Publication Date:
OSTI Identifier:
5405500
Resource Type:
Journal Article
Journal Name:
Behavioral Neuroscience; (USA)
Additional Journal Information:
Journal Volume: 103:4; Journal ID: ISSN 0735-7044
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HIPPOCAMPUS; BIOLOGICAL RADIATION EFFECTS; BEHAVIOR; LEARNING; NEONATES; NERVES; PREGNANCY; RATS; ANIMALS; BIOLOGICAL EFFECTS; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; MAMMALS; NERVOUS SYSTEM; ORGANS; RADIATION EFFECTS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Mickley, G A, Ferguson, J L, Nemeth, T J, Mulvihill, M A, and Alderks, C E. Spontaneous perseverative turning in rats with radiation-induced hippocampal damage. United States: N. p., 1989. Web. doi:10.1037/0735-7044.103.4.722.
Mickley, G A, Ferguson, J L, Nemeth, T J, Mulvihill, M A, & Alderks, C E. Spontaneous perseverative turning in rats with radiation-induced hippocampal damage. United States. https://doi.org/10.1037/0735-7044.103.4.722
Mickley, G A, Ferguson, J L, Nemeth, T J, Mulvihill, M A, and Alderks, C E. 1989. "Spontaneous perseverative turning in rats with radiation-induced hippocampal damage". United States. https://doi.org/10.1037/0735-7044.103.4.722.
@article{osti_5405500,
title = {Spontaneous perseverative turning in rats with radiation-induced hippocampal damage},
author = {Mickley, G A and Ferguson, J L and Nemeth, T J and Mulvihill, M A and Alderks, C E},
abstractNote = {This study found a new behavioral correlate of lesions specific to the dentate granule cell layer of the hippocampus: spontaneous perseverative turning. Irradiation of a portion of the neonatal rat cerebral hemispheres produced hypoplasia of the granule cell layer of the hippocampal dentate gyrus while sparing the rest of the brain. Radiation-induced damage to the hippocampal formation caused rats placed in bowls to spontaneously turn in long, slow bouts without reversals. Irradiated subjects also exhibited other behaviors characteristic of hippocampal damage (e.g., perseveration in spontaneous exploration of the arms of a T-maze, retarded acquisition of a passive avoidance task, and increased horizontal locomotion). These data extend previously reported behavioral correlates of fascia dentata lesions and suggest the usefulness of a bout analysis of spontaneous bowl turning as a measure of nondiscrete-trial spontaneous alternation and a sensitive additional indicator of radiation-induced hippocampal damage.},
doi = {10.1037/0735-7044.103.4.722},
url = {https://www.osti.gov/biblio/5405500}, journal = {Behavioral Neuroscience; (USA)},
issn = {0735-7044},
number = ,
volume = 103:4,
place = {United States},
year = {Tue Aug 01 00:00:00 EDT 1989},
month = {Tue Aug 01 00:00:00 EDT 1989}
}