Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication

Sayle, B A; Helmer, R E; Birdsong, B A; Balachandran, S; Gardner, F H

Title: Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication

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Abstract

Twenty-nine patients with aplastic anemia and 11 patients with myelofibrosis were evaluated with indium-111 chloride bone-marrow imaging, ferrokinetics, and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the In-111 bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy had been taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was good correlation between the plasma iron clearance t1/2 and the scan grade. Less agreement was found in the comparison between the Fe-59 sacral and organ counts and the red-cell iron utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell iron utilization. Plasma iron clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics, and the patient's response to therapy. Indium-111 bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases.

Authors:: Sayle, B A; Helmer, R E; Birdsong, B A; Balachandran, S; Gardner, F H

Publication Date:: Mon Feb 01 00:00:00 EST 1982

Research Org.:: University of Texas Medical Branch, Galveston

OSTI Identifier:: 5405169

Resource Type:: Journal Article

Journal Name:: J. Nucl. Med.; (United States)

Additional Journal Information:: Journal Volume: 23:2

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; SCINTISCANNING; INDIUM 111; IRON 59; BLOOD-PLASMA CLEARANCE; ANEMIAS; ERYTHROCYTES; FIBROSIS; INDIUM CHLORIDES; PATIENTS; TRANSFERRIN; ANIMAL TISSUES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CHLORIDES; CHLORINE COMPOUNDS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLOBULINS; GLOBULINS-BETA; HALIDES; HALOGEN COMPOUNDS; HEMATOPOIETIC SYSTEM; HEMIC DISEASES; INDIUM COMPOUNDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; IRON ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MATERIALS; METALLOPROTEINS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPTOMS; TISSUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Sayle, B A, Helmer, R E, Birdsong, B A, Balachandran, S, and Gardner, F H. Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication.  United States: N. p., 1982. 
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                    Sayle, B A, Helmer, R E, Birdsong, B A, Balachandran, S, & Gardner, F H. Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication.  United States.

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                    Sayle, B A, Helmer, R E, Birdsong, B A, Balachandran, S, and Gardner, F H. 1982.  
        "Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication".  United States.

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@article{osti_5405169,

  title        = {Bone-marrow imaging with indium-111 chloride in aplastic anemia and myelofibrosis: concise communication},

  author       = {Sayle, B A and Helmer, R E and Birdsong, B A and Balachandran, S and Gardner, F H},

  abstractNote = {Twenty-nine patients with aplastic anemia and 11 patients with myelofibrosis were evaluated with indium-111 chloride bone-marrow imaging, ferrokinetics, and bone-marrow core biopsies. There was good correlation between the erythrocyte cellularity of the marrow and the In-111 bone-marrow scan grades in most patients. In some, the overall scan grade tended to underestimate the erythroid elements because the core biopsy had been taken from the area of the greatest radionuclide concentration on the scan. In patients with aplastic anemia, there was good correlation between the plasma iron clearance t1/2 and the scan grade. Less agreement was found in the comparison between the Fe-59 sacral and organ counts and the red-cell iron utilization. In patients with myelofibrosis, there was poor correlation between the surface counts over the sacrum and the red-cell iron utilization. Plasma iron clearances were abnormally short and were unrelated to the transferrin saturation levels. Eighteen patients were studied several times to evaluate their responses to steroid therapy. In all, there was good correlation between the bone-marrow imaging, the erythrocyte cellularity, ferrokinetics, and the patient's response to therapy. Indium-111 bone-marrow imaging is useful both in evaluating marrow erythroid activity and in following the response to therapy in patients with these diseases.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5405169},
  journal      = {J. Nucl. Med.; (United States)},
number       = ,

  volume       = 23:2,

  place        = {United States},

  year         = {Mon Feb 01 00:00:00 EST 1982},

  month        = {Mon Feb 01 00:00:00 EST 1982}

}

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