Review of approaches to the detection of genetic damage in the human fetus
Studies in experimental animals links between genetic damage to the fetus and the etiology of several disorders, including fetal loss, teratogenesis, and cancer. Methods for measuring genetic damage directly in the human fetus could provide epidemiologists and clinical researchers with powerful tools for investigating similar associations in humans. Current methods potentially available for such studies include assays for mutagenic substances in human body fluids and for measuring modifications to genetic material at the three levels of organization of genetic material: the chromosome, the gene or specific locus, and chemical DNA. Results of studies using fetal tissues to investigate each of these end points are reviewed, emphasizing studies of chemical modifications to DNA nucleotides detected in the human plancenta.
- Research Organization:
- National Institute of Environmental Health Sciences, Research Triangle Park, NC
- OSTI ID:
- 5394048
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 74
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEREDITARY DISEASES
DIAGNOSIS
ETIOLOGY
PREGNANCY
BIOLOGICAL MARKERS
CARCINOGENESIS
CHROMOSOMES
DNA
EPIDEMIOLOGY
FETUSES
MUTAGENS
NEOPLASMS
NUCLEOTIDES
PHOSPHORUS 32
PLACENTA
RISK ASSESSMENT
SISTER CHROMATID EXCHANGES
TERATOGENESIS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHROMOSOMAL ABERRATIONS
DAYS LIVING RADIOISOTOPES
DISEASES
FETAL MEMBRANES
ISOTOPES
LIGHT NUCLEI
MEMBRANES
MUTATIONS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology