Intact coding region of the serotonin transporter gene in obsessive-compulsive disorder
- NIMH, NIH, Bethesda, MD (United States)
- Univ. of Wuerzburg (Germany)
Epidemiologic studies indicate that obsessive-compulsive disorder is genetically transmitted in some families, although no genetic abnormalities have been identified in individuals with this disorder. The selective response of obsessive-compulsive disorder to treatment with agents which block serotonin reuptake suggests the gene coding for the serotonin transporter as a candidate gene. The primary structure of the serotonin-transporter coding region was sequenced in 22 patients with obsessive-compulsive disorder, using direct PCR sequencing of cDNA synthesized from platelet serotonin-transporter mRNA. No variations in amino acid sequence were found among the obsessive-compulsive disorder patients or healthy controls. These results do not support a role for alteration in the primary structure of the coding region of the serotonin-transporter gene in the pathogenesis of obsessive-compulsive disorder. 27 refs.
- OSTI ID:
- 539393
- Journal Information:
- American Journal of Medical Genetics, Vol. 67, Issue 4; Other Information: PBD: 26 Jul 1996
- Country of Publication:
- United States
- Language:
- English
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