skip to main content

Title: Variations in the distribution of selenium between erythrocyte glutathione peroxidase and hemoglobin in different human populations

The majority of erythrocyte (RBC) selenium (Se) is associated with glutathione peroxidase (GPx) in animals, but most of it is with hemoglobin (Hb) in human RBCs. Dietary forms of Se may influence this distribution since a rat study showed that selenite promoted the deposition of Se in GPx but selenomethionine (SeMet) resulted in greater amounts with Hb. Three different populations of people were chosen to investigate some possible reasons for the Se distribution in human RBC proteins. An average of 12% of the RBC Se (0.71 ng Se/mg Hb) was associated with GPx in people living in Oregon, but nearly 30% of the Se was associated with GPx in RBC (0.26 ng Se/mg Hb) from New Zealanders. Georgia residents with low RBC Se levels (0.35 ng Se/mg Hb) had 38% of the Se associated with GPx as compared to 29% for those with higher RBC levels (0.56 ng Se/mg Hb). In a third group of people the amount of Se tended to be higher in RBC GPx from non-vegetarian OSU students than from vegetarians. The predominant form of Se in meat appears to be selenocysteine, which is metabolized similarly to selenite, and presumably contributes to this difference since many plantmore » foods contain Se as SeMet. These are examples of many possible factors affecting the relative distribution of Se in human RBC proteins.« less
Authors:
; ; ; ;
Publication Date:
OSTI Identifier:
5392744
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA
Resource Type:
Conference
Resource Relation:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Research Org:
Oregon State Univ., Corvallis
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; SELENIUM; METABOLISM; TISSUE DISTRIBUTION; ERYTHROCYTES; FOOD; GEORGIA; HEMOGLOBIN; MAN; NEW ZEALAND; OREGON; PEROXIDASES; ANIMALS; AUSTRALASIA; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARBOXYLIC ACIDS; DISTRIBUTION; ELEMENTS; ENZYMES; FEDERAL REGION IV; FEDERAL REGION X; GLOBIN; HETEROCYCLIC ACIDS; HETEROCYCLIC COMPOUNDS; MAMMALS; MATERIALS; NORTH AMERICA; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; OXIDOREDUCTASES; PIGMENTS; PORPHYRINS; PRIMATES; PROTEINS; SEMIMETALS; USA; VERTEBRATES 550500* -- Metabolism