Dopamine DRD2/Cys311 is not associated with chronic schizophrenia

Journal Article · Fri Sep 20 00:00:00 EDT 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19960920)67:5<483::AID-AJMG8>3.0.CO;2-L· OSTI ID:539229

Crawford, F; Hoyne, J; Cai, Xingang ^[1]

---

1. Univ. of South Florida, Tampa, FL (United States); and others

A mutation in the DRD2 receptor gene has been reported in association with schizophrenia in Japanese and Caucasian populations. The variation, Ser to Cys at codon 311, occurs in the third intracellular loop of the receptor and is therefore putatively functional. We report the results of screening US Caucasian schizophrenic and nonschizophrenic populations. We detected the occurrence of the DRD2 Cys311 variant in both schizophrenics and controls. Our data demonstrates no significant difference between the frequency of Cys311 in Caucasian schizophrenic and non-schizophrenic populations, indicating no association with schizophrenia. 8 refs., 1 fig., 1 tab.

• OSTI ID: 539229
• Journal Information: American Journal of Medical Genetics, Vol. 67, Issue 5; Other Information: PBD: 20 Sep 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENE MUTATIONS
DETECTION
PATIENTS
HEREDITARY DISEASES
MENTAL DISORDERS
NERVOUS SYSTEM DISEASES
BEHAVIOR
DOPAMINE
GENETIC MAPPING
RECEPTORS
DNA SEQUENCING
MUTATION FREQUENCY
AMINO ACID SEQUENCE
CODONS
POLYMERASE CHAIN REACTION