Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity

Yang, H K; Cain, C A; Lockwood, J; Tompkins, W A

doi:10.1002/bem.2250040204

Title: Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity

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Abstract

Hamsters were exposed to repeated or single doses of microwave energy and monitored for changes in core body temperature, circulating leukocyte profiles, serum corticosteroid levels, and natural killer (NK) cell activity in various tissues. NK cytotoxicity was measured in a /sup 51/Cr-release assay employing baby hamster kidney (BHK) targets or BHK infected with herpes simplex virus. Repeated exposure of hamsters at 15 mW/cm2 for 60 min/day had no significant effect on natural levels of spleen-cell NK activity against BHK targets. Similarly, repeated exposure at 15 mW/cm2 over a 5-day period had no demonstrable effect on the induction of spleen NK activity by vaccinia virus immunization, that is, comparable levels of NK were induced in untreated and microwave-treated animals. In contrast, treatment of hamsters with a single 60-min microwave exposure at 25 mW/cm2 caused a significant suppression in induced spleen NK activity. A similar but less marked decrease in spleen NK activity was observed in sham-exposed animals. Moreover, the sham effects on NK activity were not predictable and appeared to represent large individual animal variations in the response to stress factors. Depressed spleen NK activity was evident as early as 4 h postmicrowave treatment and returned to normal levels by 8more »« less

Authors:: Yang, H K; Cain, C A; Lockwood, J; Tompkins, W A

Publication Date:: Sat Jan 01 00:00:00 EST 1983

Research Org.:: Department of Pathobiology, University of Illinois, Urbana-Champaign

OSTI Identifier:: 5390251

Resource Type:: Journal Article

Journal Name:: Bioelectromagnetics (N.Y.); (United States)

Additional Journal Information:: Journal Volume: 4:2

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MICROWAVE RADIATION; IMMUNOSUPPRESSION; CORTICOSTEROIDS; HAMSTERS; HYPERTHERMIA; KIDNEYS; LEUKOCYTES; SPLEEN; SPLEEN CELLS; ADRENAL HORMONES; ANIMAL CELLS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; BODY TEMPERATURE; ELECTROMAGNETIC RADIATION; HORMONES; HYDROXY COMPOUNDS; KETONES; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PREGNANES; RADIATIONS; RODENTS; SOMATIC CELLS; STEROID HORMONES; STEROIDS; VERTEBRATES; 560400* - Other Environmental Pollutant Effects

Citation Formats


                    Yang, H K, Cain, C A, Lockwood, J, and Tompkins, W A. Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity.  United States: N. p., 1983. 
        Web.  doi:10.1002/bem.2250040204.

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                    Yang, H K, Cain, C A, Lockwood, J, & Tompkins, W A. Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity.  United States.  https://doi.org/10.1002/bem.2250040204

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                    Yang, H K, Cain, C A, Lockwood, J, and Tompkins, W A. 1983.  
        "Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity".  United States.  https://doi.org/10.1002/bem.2250040204.

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@article{osti_5390251,

  title        = {Effects of microwave exposure on the hamster immune system. I. Natural killer cell activity},

  author       = {Yang, H K and Cain, C A and Lockwood, J and Tompkins, W A},

  abstractNote = {Hamsters were exposed to repeated or single doses of microwave energy and monitored for changes in core body temperature, circulating leukocyte profiles, serum corticosteroid levels, and natural killer (NK) cell activity in various tissues. NK cytotoxicity was measured in a /sup 51/Cr-release assay employing baby hamster kidney (BHK) targets or BHK infected with herpes simplex virus. Repeated exposure of hamsters at 15 mW/cm2 for 60 min/day had no significant effect on natural levels of spleen-cell NK activity against BHK targets. Similarly, repeated exposure at 15 mW/cm2 over a 5-day period had no demonstrable effect on the induction of spleen NK activity by vaccinia virus immunization, that is, comparable levels of NK were induced in untreated and microwave-treated animals. In contrast, treatment of hamsters with a single 60-min microwave exposure at 25 mW/cm2 caused a significant suppression in induced spleen NK activity. A similar but less marked decrease in spleen NK activity was observed in sham-exposed animals. Moreover, the sham effects on NK activity were not predictable and appeared to represent large individual animal variations in the response to stress factors. Depressed spleen NK activity was evident as early as 4 h postmicrowave treatment and returned to normal levels by 8 h. Hamsters exposed at 25 mW/cm2 showed an elevated temperature of 3.0-3.5 degrees C that returned to normal within 60 min after termination of microwave exposure. These animals also showed a marked lymphopenia and neutrophilia by 1 h posttreatment that returned to normal by 8-10 h. Serum glucocorticosteroids were elevated between 1 aNd 8 h after microwave treatment. Sham-exposed animals did not demonstrate significant changes in core body temperature, peripheral blood leukocyte (PBL) profile, or glucocorticosteroid levels as compared to minimum-handling controls.},

  doi          = {10.1002/bem.2250040204},

  url          = {https://www.osti.gov/biblio/5390251},
  journal      = {Bioelectromagnetics (N.Y.); (United States)},
number       = ,

  volume       = 4:2,

  place        = {United States},

  year         = {Sat Jan 01 00:00:00 EST 1983},

  month        = {Sat Jan 01 00:00:00 EST 1983}

}

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