Evaluation of toxicity of river sediments by in vitro enzyme inhibition
- Science Univ. of Tokyo (Japan)
To confirm the presence of toxic substances in aquatic environments, various toxicological assays have been carried out. Latent toxicity cannot be evaluated only by chemical analysis since natural samples contain diverse kinds of compounds. On the other hand a biological assay should be appropriate for evaluating directly latent toxicity. Many biological toxic examinations have been conducted on fish, shellfish, algae, zooplankton and others using the whole body. Another method for evaluating of toxicity of environmental samples has been to use enzyme inhibition in vitro. The authors have investigated the distribution of cholinesterase inhibitor in the river sediment and evaluated the latent toxicity of aquatic environment samples. The present paper reports the inhibitory effects of solvent extracts from Tama and Ayase River sediments on three enzymes: alkaline phosphatase and glucose-6-phosphate dehydrogenase that diagnose for a functional disorder of a liver and {beta}-glucuronidase for that of a kidney used in clinical inspection.
- OSTI ID:
- 5388473
- Journal Information:
- Bulletin of Environmental Contamination and Toxicology; (United States), Vol. 44:6; ISSN 0007-4861
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ALKALINE PHOSPHATASE
ENZYME ACTIVITY
GLUCURONIDASE
SEDIMENTS
SOLVENT EXTRACTION
WATER POLLUTION
TOXICITY
BIOASSAY
HEMIACETAL DEHYDROGENASES
IN VITRO
JAPAN
KIDNEYS
QUANTITATIVE CHEMICAL ANALYSIS
ASIA
BODY
CHEMICAL ANALYSIS
DEVELOPED COUNTRIES
ENZYMES
ESTERASES
EXTRACTION
GLYCOSYL HYDROLASES
HYDROLASES
O-GLYCOSYL HYDROLASES
ORGANS
OXIDOREDUCTASES
PHOSPHATASES
POLLUTION
SEPARATION PROCESSES
560300* - Chemicals Metabolism & Toxicology