Lead and selenium effects on glutathione metabolism in the chick
The effects of lead (Pb) and selenium (Se) on certain aspects of glutathione (GSH) turnover in the chick were examined in a series of 2 x 2 factorial experiments. Organ GSH, total non-protein sulfhydryl (NPSH), and GSH-related amino acid concentrations were measured in chicks fed a glucose-soybean meal diet supplemented with 0 or 2000 ppm Pb as Pb acetate x /sup 3/H/sub 2/O and 0 or 20 ppm Se as Na/sub 2/SeO/sub 3/ from 1 to 21 days of age. Significant changes in the concentrations of GSH, NPSH, glutamate (GLU), glucine (GLY), methionine (MET), and cystine (CYS) in liver, kidneys, and plasma due to Pb and Se administration are described. Plasma CYS and MET tended to be lowered, though not always significantly (NS), by both Pb and Se. Liver MET was decreased (NS) by Se, but increased (P < 0.05) by Pb. Liver NPSH and GSH were increased (NS) by Pb. These data suggest an enhancement of GSH turnover by toxic levels of both Pb and Se, possibly by different mechanisms. Further research on mechanisms of the Pb and Se effects are planned.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 5381912
- Report Number(s):
- CONF-8604222-; TRN: 86-026831
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
GLUTATHIONE
METABOLISM
LEAD
BIOLOGICAL EFFECTS
SELENIUM
BLOOD PLASMA
CHICKENS
KIDNEYS
LIVER
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
BIOLOGICAL MATERIALS
BIRDS
BLOOD
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
FOWL
GLANDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MATERIALS
METALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOPROTECTIVE SUBSTANCES
SEMIMETALS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
550501 - Metabolism- Tracer Techniques