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Title: Metabolic effects of carbohydrate-copper interactions in swine

Inadequate dietary copper(Cu) is known to elicit several undesirable metabolic changes in humans and rats. Abnormal cardiac function, including sudden death is a common finding in copper deficient (CuD) rats, especially those fed diets with a high fructose (FR) content. Swine were chosen as the animal model for this project since their circulatory system is morphologically similar to that of humans. In an effort to further study these dietary effects 12 male and 12 female swine were randomly assigned to 4 groups of 6 pigs each and fed CuD and Cu supplemented (CuS) diets with 20% of calories from either FR or glucose (GL) for a period of 10 weeks. In agreement with data from recent experiments, CuD swine exhibited anemia, decreased ceruloplasmin, Cu-Zn superoxide dismutase and serum Cu; however, serum cholesterol and triglycerides decreased significantly when the animals were fed the CuD diets as compared to those fed CuS diets. Serum glutamic pyruvic transaminase (SGPT) activity was lowest for pigs fed the CuD FR diet compared to the CuS and CuD Gl groups during the study. SGPT activity usually increases when humans consume high FR diets. The results of these analyses indicate that swine are an acceptable model formore » the study of dietary CuD, although some indices give inverse results compared to those seen in rats and humans.« less
Authors:
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Publication Date:
OSTI Identifier:
5381865
Report Number(s):
CONF-8604222-
Journal ID: CODEN: FEPRA
Resource Type:
Conference
Resource Relation:
Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States); Journal Volume: 45:3; Conference: 70. annual meeting of the Federation of American Society for Experimental Biology, St. Louis, MO, USA, 13 Apr 1986
Research Org:
Dept. of Agriculture, Beltsville, MD
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; AMINOTRANSFERASES; ENZYME ACTIVITY; COPPER; BIOLOGICAL EFFECTS; NUTRITIONAL DEFICIENCY; ANEMIAS; BIOLOGICAL MODELS; CHOLESTEROL; DIET; FRUCTOSE; GLUCOSE; METABOLISM; SUPEROXIDE DISMUTASE; SWINE; SYNERGISM; TRIGLYCERIDES; ALDEHYDES; ANIMALS; CARBOHYDRATES; DISEASES; DOMESTIC ANIMALS; ELEMENTS; ENZYMES; ESTERS; HEMIC DISEASES; HEXOSES; HYDROXY COMPOUNDS; KETONES; LIPIDS; MAMMALS; METALS; MONOSACCHARIDES; NITROGEN TRANSFERASES; ORGANIC COMPOUNDS; OXIDOREDUCTASES; SACCHARIDES; STEROIDS; STEROLS; SYMPTOMS; TRANSFERASES; TRANSITION ELEMENTS; VERTEBRATES 560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)