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Title: Functionally active ganglioneuroma with increased plasma and urinary catecholamines and positive iodine 131-meta-iodobenzylguanidine scintigraphy

Ganglioneuromas are usually considered not to be functionally active. Studies of their catecholamine excretory pattern and of their imaging by means of the adrenergic tracing agent 131-I-MIBG have been therefore sparse. We report on a case of secretory ganglioneuroma, as demonstrated by the increased urinary excretion of the catecholamine metabolites HVA and VMA, increased plasma dopamine and epinephrine levels, and positive 131-I-MIBG scintigraphy. We must therefore be aware that a functionally active tumor is not necessarily a neuroblastoma, and that the diagnosis should be biopsy proven.
Authors:
; ; ; ; ;  [1]
  1. (Univ. La Sapienza, Rome (Italy))
Publication Date:
OSTI Identifier:
5381460
Resource Type:
Journal Article
Resource Relation:
Journal Name: Medical and Pediatric Oncology; (United States); Journal Volume: 19:4
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ADRENALINE; BIOSYNTHESIS; CATECHOLAMINES; RENAL CLEARANCE; DOPAMINE; NEOPLASMS; DIAGNOSIS; IODINE 131; SCINTISCANNING; ADRENAL HORMONES; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; CLEARANCE; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EXCRETION; HORMONES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SYMPATHOMIMETICS; SYNTHESIS 550601* -- Medicine-- Unsealed Radionuclides in Diagnostics