Effect of N-methylformamide on radiocurability of murine tumors

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577192· OSTI ID:5379927

Iwakawa, M; Milas, L

N-Methylformamide (NMF) is a polar solvent with maturational activity, i.e., it induces malignant cells to form more differentiated phenotypes. In addition, it renders tumor cells more sensitive to chemotherapeutic drugs and ionizing radiation. In the present study, NMF failed to augment radiocurability, as measured by the single-dose TCD50 assay, of two murine tumors: an 8-mm fibrosarcoma (FSA) and a 6-mm mammary carcinoma (MCA-K). NMF, at a dose of 300 mg/kg, was given ip daily for several days before and/or after local tumor irradiation.

• Research Organization: Univ. of Texas, M. D. Anderson Hospital and Tumor Institute, Houston (USA)
• OSTI ID: 5379927
• Journal Information: Radiat. Res.; (United States), Vol. 113:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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RADIOSENSITIVITY EFFECTS
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