Primary radiation therapy in the treatment of anal carcinoma

Conference · Thu Sep 01 00:00:00 EDT 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:5377242

Cantril, S T ^[1]; Green, J P; Schall, G L; Schaupp, W C

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1. Children's Hospital of San Francisco, CA

From 1966 to 1981, 47 patients with a diagnosis of anal carcinoma were irradiated. This group was composed of 23 males and 24 females, with age ranging from 38 to 84 years (average 64.4 years). Five patients were treated preoperatively and 34 were treated definitively with cancericidal doses of irradiation. Acute radiation reactions requiring a rest-break were noted in 28% of patients, but all were managed as outpatients without untoward chronic sequelae. Chronic complications were noted in 13 patients, including two patients who required colostomy for severe anal stenosis and two who required A-P resection for large painful ulcers. Twenty-eight of 35 patients (80%) treated with irradiation alone have remained locally controlled without further treatment. An additional four have been salvaged by surgery. Only three patients had interstitial implants as part of their treatment course. Actuarial survival at five years for the N/sub 0/ patients and the group as a whole are 95.6 and 79.3%, respectively. It is concluded that external beam irradiation alone, properly fractionated to cancericidal doses, can control anal carcinoma with acceptable morbidity rates and without the use of either chemotherapy or interstitial implants in most cases. There is also a strong correlation suggesting that anal intercourse and male homosexuality play a significant role in the etiology of this disease.

• OSTI ID: 5377242
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:9
• Country of Publication: United States
• Language: English

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GASTROINTESTINAL TRACT
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INTESTINES
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IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
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LARGE INTESTINE
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
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NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION SOURCES
RADIATIONS
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