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Title: Prevention of anemia alleviates heart hypertrophy in copper deficient rats

The present investigation was designed to examine the role of anemia in the cardiomegaly and myocardial pathology of copper deficiency. Weanling rats were fed a copper deficient diet containing either starch (ST) or fructose (FRU) for five weeks. Six rats consuming the FRU diet were intraperitoneally injected once a week with 1.0 ml/100g bw of packed red blood cells (RBC) obtained from copper deficient rats fed ST. FRU rats injected with RBC did not develop anemia. Additionally, none of the injected rats exhibited heart hypertrophy or gross pathology and all survived. In contrast, non-injected FRU rats were anemic, exhibited severe signs of copper deficiency which include heart hypertrophy with gross pathology, and 44% died. Maintaining the hematocrit with RBC injections resulted in normal heart histology and prevented the mortality associated with the fructose x copper interaction. The finding suggest that the anemia associated with copper deficiency contributes to heart pathology.
Authors:
; ;  [1]
  1. (Dept. of Agriculture, Beltsville, MD (United States) Univ. of Maryland, College Park (United States) Georgetown Univ., Washington, DC (United States))
Publication Date:
OSTI Identifier:
5373092
Report Number(s):
CONF-9104107--
Journal ID: ISSN 0892-6638; CODEN: FAJOE
Resource Type:
Conference
Resource Relation:
Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States); Journal Volume: 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ANEMIAS; PATHOGENESIS; COPPER; BIOLOGICAL EFFECTS; HEART; PATHOLOGICAL CHANGES; BLOOD COUNT; ERYTHROCYTES; FRUCTOSE; METABOLISM; NUTRITIONAL DEFICIENCY; RATS; STARCH; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARBOHYDRATES; CARDIOVASCULAR SYSTEM; DISEASES; ELEMENTS; HEMIC DISEASES; HEXOSES; KETONES; MAMMALS; MATERIALS; METALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; POLYSACCHARIDES; REAGENTS; RODENTS; SACCHARIDES; SYMPTOMS; TRANSITION ELEMENTS; VERTEBRATES 560300* -- Chemicals Metabolism & Toxicology